Alzheimers disease is a severe neurodegenerative disorder and the most common cause of dementia in the population above 60 years of age. Beta-amyloid accumulation and neurofibrillary tangles formation in the brain precedes the development of Alzheimer's dementia by many years. As beta-amyloid accumulation inhibition failed as a treatment option, the theories on the Alzheimers disease pathophysio-lo-gy are being revised. In this context, research targets the role of inflammation as the possible trigger mechanism and accompanying process of neurodegeneration. This article summarizes some knowledge of the immune function of brain cells and its potential relation to Alzheimers disease progression in the light of the immune reaction hypothesis.

• Klíčová slova
• Alzheimers disease - immune response - inflammation - brain cells.,
• MeSH
• Alzheimerova nemoc * imunologie   patofyziologie   MeSH
• imunitní systém * imunologie   patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH