Relatively little is known about the spatial organization of RNA synthesis, processing, and transport in (mammalian) cell nuclei. This review summarizes results of electron microscopic mapping of RNA synthetic sites and macromolecules involved directly, or indirectly, in the metabolism of RNAs in somatic cell mammalian nuclei. Significance of these results will be discussed in the context of the molecular mechanisms underlying spatial arrangements of RNA metabolism.

• MeSH
• Cell Nucleolus ultrastructure   MeSH
• Cell Nucleus metabolism   ultrastructure   MeSH
• Chromatin metabolism   MeSH
• Microscopy, Electron MeSH
• Humans MeSH
• RNA Processing, Post-Transcriptional * MeSH
• RNA biosynthesis   metabolism   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH
• Names of Substances
• Chromatin MeSH
• RNA MeSH