Onemocnění sítnice Dotaz Zobrazit nápovědu
- MeSH
- lidé MeSH
- nemoci retiny diagnóza MeSH
- testy zrakového pole přístrojové vybavení metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The aim of this review is to provide a comprehensive summary of current gene therapy clinical trials for monogenic and optic nerve disorders.The number of genes for which gene-based therapies are being developed is growing. At the time of writing this review gene-based clinical trials have been registered for Leber congenital amaurosis 2 (LCA2), retinitis pigmentosa 38, Usher syndrome 1B, Stargardt disease, choroideremia, achromatopsia, Leber hereditary optic neuropathy (LHON) and X-linked retinoschisis. Apart from RPE65 gene therapy for LCA2 and MT-ND4 for LHON which has reached phase III, all other trials are in investigation phase I and II, i.e. testing the efficacy and safety.Because of the relatively easy accessibility of the retina and its ease of visualization which allows monitoring of efficacy, gene-based therapies for inherited retinal disorders represent a very promising treatment option. With the development of novel therapeutic approaches, the importance of establishing not only clinical but also molecular genetic diagnosis is obvious.Key words: gene therapy, monogenic retinal diseases, optic nerve atrophy, mitochondrial disease.
- MeSH
- dědičné nemoci očí terapie MeSH
- genetická terapie metody MeSH
- lidé MeSH
- nemoci retiny genetika terapie MeSH
- nemoci zrakového nervu genetika terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- degenerace retiny farmakoterapie MeSH
- diabetická retinopatie farmakoterapie MeSH
- enzymoterapie * MeSH
- glykosaminoglykany MeSH
- injekce intramuskulární MeSH
- lidé MeSH
- oční nemoci farmakoterapie MeSH
- retina * MeSH
- retinální krvácení farmakoterapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- glykosaminoglykany MeSH
- MeSH
- aneurysma diagnóza MeSH
- dospělí MeSH
- lidé MeSH
- retinální cévy * MeSH
- retinitida diagnóza MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
- Klíčová slova
- RETINA/diseases *,
- MeSH
- lidé MeSH
- nemoc * MeSH
- nemoci retiny * MeSH
- retina * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: This is 23-years retrospective study of consecutive, non-selected patients with senile retinoschisis and rare progressive and symptomatic retinal detachment (RD). The presence of RD was manifested by spectrum of retinal pathology of inner and outer layers of senile retinoschisis, ranging from simple holes to giant tears with or without proliferative vitreoretinopathy. The goals of this study were: 1--to evaluate the characteristics of the progressive and symptomatic RD based on detail preoperative examination of the eye, 2--to evaluate the anatomic and functional results of RD surgery. PATIENTS AND METHODS: From 1978 to 1999, RD surgery was performed on 57 eyes of 55 patients (28 men and 27 women) with senile retinoschisis and progressive and symptomatic RD. On average, we observed the patients for approximately 11.3 years after surgery; the minimum follow-up period was 20 months. The patients were divided in two groups according to the preoperative findings and the surgical procedures. Based on the size and the location of the defects of the inner and outer layer of senile retinoschisis and the proliferative vitreoretinopathy these procedures were indicated: 1--Uncomplicated cases of progressive and symptomatic retinal detachment were operated on primary cryopexy and scleral buckling (CSB) with episcleral silicone implants in 45 eyes. 2--Complicated cases of progressive and symptomatic retinal detachment underwent a pars plana vitrectomy (PPV) in 12 eyes: a--primary PPV was used as the primary treatment method in 6 eyes, b--secondary PPV as a secondary treatment method after unsuccessfully primary CSB with episcleral silicone implants in next 6 eyes. RESULTS: Characteristics preoperative findings were: RD in two or more quadrants in 84.2% of the eyes, including macula region in 71.9% of the eyes. Defect of the outer layer of senile retinoschisis was located postequatorial in 80% of the eyes, large retinal tears were found in 53.3% of the eyes and single defect was diagnosed in 68.8% of the eyes. Defect the of inner layer of senile retinoschisis was located equatorial in 69.5% of the eyes, small defects were found in 78.2% of the eyes and multiple defects were diagnosed in 58.6% of the eyes. Defects of the outer and the inner layer of senile retinoschisis were diagnosed in the equal quadrant in 61.4% of the eyes. The results of surgery varied, depending on the size and location of the defects of the inner and outer layer of senile retinoschisis and proliferative vitreoretinopathy: 1--The complete retinal reattachment in group treated with CSB was achieved in 43 eyes (95.5%), the average visual acuity was 0.34-2--The complete retinal reattachment in group treated with PPV was achieved by: a--primary PPV in six eyes, the average visual acuity was 0.37, b--secondary PPV four eyes, the average visual acuity was 0.16. CONCLUSIONS: Characteristic of senile retinoschisis, especially its defects of inner and outer layers is important preoperative finding for optimal indication of primary surgical treatment of progressive and symptomatic retinal detachment. According to our clinical experiences we created the syllabus of the care about the senile retinoschisis and syllabus of surgical treatment of progressive and symptomatic RD. Standard surgical procedures are the CSB and in the last period also primary PPV.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- odchlípení sítnice komplikace patologie patofyziologie chirurgie MeSH
- progrese nemoci MeSH
- retinoschisis komplikace MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- zraková ostrost MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- MeSH
- časové faktory MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci cév etiologie MeSH
- nemoci retiny komplikace MeSH
- retinální cévy * MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- cizí těleso v oku diagnóza MeSH
- cysty diagnóza MeSH
- dospělí MeSH
- granulom diagnóza MeSH
- lidé MeSH
- nemoci retiny diagnóza MeSH
- reakce na cizí těleso diagnóza MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
UNLABELLED: Retinal diseases represent a large group of hereditary and acquired diseases that often lead to loss of vision. There is currently no effective treatment of retinal degeneration, only supportive therapy is used for treating numerous diseases. Perspective treatment of retinal diseases represent a cell therapy using stem cells. Suitable candidates for the stem cell therapy are mesenchymal stem cells due to their differentiating properties, protective effect and also immunomodulation. KEY WORDS: retinal disease, therapy, stem cells, mesenchymal stem cells.
- MeSH
- hyperbarická oxygenace * MeSH
- lidé středního věku MeSH
- lidé MeSH
- metody MeSH
- nemoci retiny terapie MeSH
- retinální cévy * MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
