• MeSH
• krysa rodu Rattus MeSH
• paměť * MeSH
• spánek REM * MeSH
• spánková deprivace * MeSH
• učení vyhýbat se MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Polysomnographic and questionnaire investigation was performed in 22 train dispatchers and in 15 employees of post transportation during one work-rest cycle. In the group of subjects well adapted to the shift work, the slow-wave-sleep reached its peak duration in the day sleep and in the first recovery night, while REM rebound took place only on the second night. In maladapted subjects, REM sleep prevailed in the day sleep as well as in the first recovery night. The alteration of sleep structure can be thus used as a sign of adaptation vs maladaptation to shift work. Sleep structure of the recovery day sleep after single night sleep deprivation may be used as a prediction of adaptation to the shift work.

• MeSH
• dospělí MeSH
• fyziologická adaptace fyziologie   MeSH
• lidé MeSH
• polysomnografie MeSH
• poruchy cirkadiánního rytmu (spánek) patofyziologie   MeSH
• průzkumy a dotazníky MeSH
• spánek REM fyziologie   MeSH
• spánek fyziologie   MeSH
• spánková deprivace patofyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

STUDY OBJECTIVES: Recurrent isolated sleep paralysis (RISP) is a rapid eye movement (REM) parasomnia characterized by a dissociative state with characteristics of REM sleep and wakefulness. Pathophysiology has not yet been clarified and very little research has been performed using objective polysomnographic measures with inconsistent results. The main aim of our study was to find whether higher REM sleep fragmentation is consistent with the theory of state dissociation or whether signs of dissociation can be detected by spectral analysis. METHODS: A total of 19 participants in the RISP group and 19 age- and gender-matched participants in the control group underwent two consecutive full-night video-polysomnography recordings with 19-channel electroencephalography. Apart from sleep macrostructure, other REM sleep characteristics such as REM sleep arousal index, percentage of wakefulness and stage shifts within REM sleep period were analyzed, as well as power spectral analysis during REM sleep. RESULTS: No difference was found in the macrostructural parameters of REM sleep (percentage of REM sleep and REM latency). Similarly, no significant difference was detected in REM sleep fragmentation (assessed by REM sleep arousal index, percentage of wakefulness and stage shifts within REM sleep). Power spectral analysis showed higher bifrontal beta activity in the RISP group during REM sleep. CONCLUSIONS: The results showed an underlying persistent trait of higher cortical activity that may predispose patients with sleep paralysis to be more likely to experience recurrent episodes, without any apparent macrostructural features including higher REM sleep fragmentation.

• Klíčová slova
• REM fragmentation, REM pathophysiology, REM sleep, REM sleep arousal index, polysomnography, power spectral analysis, recurrent isolated sleep paralysis,
• MeSH
• bdění fyziologie   MeSH
• elektroencefalografie MeSH
• lidé MeSH
• polysomnografie MeSH
• spánek REM * fyziologie   MeSH
• spánek fyziologie   MeSH
• spánková paralýza * komplikace   MeSH
• stadia spánku fyziologie   MeSH
• studie případů a kontrol MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Sleep is regulated by complex biological systems and environmental influences, neither of which is fully clarified. This study demonstrates differential effects of partial sleep deprivation (SD) on sleep architecture and psychomotor vigilance task (PVT) performance using two different protocols (sequentially) that each restricted daily sleep to 3 hours in healthy adult men. The protocols differed only in the period of sleep restriction; in one, sleep was restricted to a 3-hour block from 12:00 AM to 3:00 AM, and in the other, sleep was restricted to a block from 3:00 AM to 6:00 AM. Subjects in the earlier sleep restriction period showed a significantly lower percentage of rapid-eye-movement (REM) sleep after 4 days (17.0 vs. 25.7 %) and a longer latency to the onset of REM sleep (L-REM) after 1 day (78.8 vs. 45.5 min) than they did in the later sleep restriction period. Reaction times on PVT performance were also better (i.e. shorter) in the earlier SR period on day 4 (249.8 vs. 272 ms). These data support the view that earlier-night sleep may be more beneficial for daytime vigilance than later-night sleep. The study also showed that cumulative declines in daytime vigilance resulted from loss of total sleep time, rather than from specific stages, and underscored the reversibility of SR effects with greater amounts of sleep.

• MeSH
• arousal fyziologie   MeSH
• cirkadiánní rytmus fyziologie   MeSH
• lidé MeSH
• mladý dospělý MeSH
• polysomnografie MeSH
• psychomotorický výkon fyziologie   MeSH
• reakční čas fyziologie   MeSH
• spánek REM fyziologie   MeSH
• spánková deprivace patofyziologie   MeSH
• Check Tag
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• MeSH
• krysa rodu Rattus MeSH
• paměť fyziologie   MeSH
• spánek REM * MeSH
• spánková deprivace * MeSH
• věkové faktory MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Rats were deprived of sleep by placing them for 36 hours in a slowly moving drum. After this procedure, during recovery sleep, the latency of onset of the first rhombencephalic - paradoxical sleep period decreased and the proportion of telencephalic/rhombencephalic - slow wave sleep reversed (during the first hour of recovery sleep). Repeated administration during the deprivation period of physostigmine (0,5 mg/kg i. p. in 30 min intervals 20-30 times) inducing in waking animals in EEG pattern close to that of rhombencephalic sleep, or atropine (1 mg/kg i. p. in 60 min intervals 10-15 times) evoking an activity resembling telencephalic sleep, did not change the above measures of recovery sleep. Pharmacologically induced sleep-like patterns did not substitute for the sleep the rats were deprived off.

• MeSH
• atropin farmakologie   MeSH
• fysostigmin farmakologie   MeSH
• krysa rodu Rattus MeSH
• spánek REM účinky léků   MeSH
• spánková deprivace * MeSH
• stadia spánku účinky léků   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• atropin MeSH
• fysostigmin MeSH

Sepsis-associated encephalopathy (SAE) is a frequent severe complication of sepsis and the systemic inflammatory response syndrome, associated with high mortality and long-term neurologic consequences in surviving patients. One of the main clinical signs of SAE are discontinuous sleep periods that are fragmented by frequent awakenings. Although this brain state fragmentation strongly impacts the functionality of the nervous and other systems, its underlying network mechanisms are still poorly understood. In this work, we therefore aim to characterize the properties and dynamics of brain oscillatory states in response to SAE in an acute rat model of sepsis induced by high-dose lipopolysaccharide (LPS; 10 mg/kg). To focus on intrinsically generated brain state dynamics, we used a urethane model that spares oscillatory activity in rapid eye movement (REM)-like and nonrapid eye movement (NREM)-like sleep states. Intraperitoneal LPS injection led to a robust instability of both oscillatory states resulting in several folds more state transitions. We identified opposing shifts in low-frequency oscillations (1-9 Hz) in REM and NREM-like states under influence of LPS. This resulted in increased similarity between both states. Moreover, the state-space jitter in both states increased as well, pointing to higher within-state instability. The reduction of interstate spectral distances in 2-D state space, combined with increased within-state jitter might represent a key factor in changing the energy landscape of brain oscillatory state attractors, and hence lead to altered sleep architecture. Their emergence during sepsis might point to a mechanism underlying severe sleep fragmentation as described both in sepsis patients and SAE animal models.

• Klíčová slova
• activity states, hippocampus, inflammation, oscillations, sepsis, sleep,
• MeSH
• elektroencefalografie metody   MeSH
• hipokampus MeSH
• kinetika MeSH
• krysa rodu Rattus MeSH
• lipopolysacharidy * MeSH
• sepse * komplikace   MeSH
• spánek REM fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• lipopolysacharidy * MeSH

• MeSH
• acetáty farmakologie   MeSH
• bdění účinky léků   MeSH
• elektroencefalografie MeSH
• lidé MeSH
• meklofenoxát farmakologie   MeSH
• spánek REM účinky léků   MeSH
• spánek účinky léků   MeSH
• spánková deprivace * MeSH
• stimulanty centrálního nervového systému farmakologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• acetáty MeSH
• meklofenoxát MeSH
• stimulanty centrálního nervového systému MeSH

The effect of paradoxical sleep deprivation (PSD) on subsequent acquisition of conditioned taste aversion (CTA) to liquid diets is confounded by the uncertain level of thirst when using the water tank procedure. This difficulty is eliminated when examining CTA and attenuation of neophobia (AN) to solid diets. Adult male rats (n = 100) were habituated to receive their daily ration of food during a 30-min stay in a box equipped with a row of 10 feeders baited with 2-3 g pieces of moist standard diet. 24-h PSD increased neophobic rejection of novel sweet food (with added 5% saccharose), but did not influence intensity of CTA elicited by LiCl poisoning. Addition of a bitter tasting red food dye to the sweet food caused marked neophobia which was enhanced by preceding PSD. Association of this unpalatable food with LiCl elicited strong CTA which extinguished faster in the PSD-pretreated animals. On the other hand, preacquisition PSD did not influence AN to the same stimulus. Sweet food with added blue dye elicited only mild neophobia which was enhanced by preceding 24-h PSD. Preacquisition PSD did not influence AN but significantly increased CTA to blue sweet food. It is concluded that PSD can either enhance or weaken CTA and that this complex effect on food selection learning cannot be explained by PSD-induced reduction of fear.

• MeSH
• chuť fyziologie   MeSH
• krysa rodu Rattus MeSH
• pátrací chování fyziologie   MeSH
• spánek REM fyziologie   MeSH
• spánková deprivace fyziologie   MeSH
• stravovací zvyklosti fyziologie   MeSH
• učení vyhýbat se fyziologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• dítě MeSH
• dospělí MeSH
• elektroencefalografie MeSH
• elektrookulografie MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• pohyby očí MeSH
• spánek REM MeSH
• spánek * MeSH
• spánková deprivace MeSH
• stadia spánku MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH