The DSM-5 Alternative Model for Personality Disorders introduced a dimensional perspective on personality disorders and their assessment by measuring personality functioning in the following domains: Identity, Self-Direction, Empathy, and Intimacy. This study provides a replication of the psychometric evaluation of the Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1) within a mixed clinical sample and a community sample. The sample consisted of 188 adults: 86 participants from the general population and 102 people from a mixed clinical sample. All participants completed the STiP-5.1 and Level of Personality Functioning Scale-Brief Form (LPFS-BF 2.0). Results showed good internal consistency (McDonald's ω = 0.89-0.94) and promising convergent validity (correlations with LPFS-BF 2.0 above 0.6) of the STiP-5.1. Its scores differentiated participants within the community sample from those in the mixed clinical sample with large effect sizes (rrb = 0.77-0.88). Moreover, the impairment in personality functioning was more pronounced in people with personality disorders than in other psychiatric disorders (medium effect size, rrb = 0.46-0.57), supporting the notion of a continuum of personality functioning impairment. The STiP-5.1 therefore offers an instrument with satisfactory psychometric properties for the assessment of personality functioning both for research and clinical practice.

• MeSH
• Diagnostický a statistický manuál mentálních poruch MeSH
• dospělí MeSH
• lidé MeSH
• osobnost * MeSH
• poruchy osobnosti * diagnóza   MeSH
• psychometrie MeSH
• reprodukovatelnost výsledků MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH

In higher plants, cell cycle activation in the meristems at germination is essential for the initiation of post-embryonic development. We previously identified the signaling pathways of homeobox transcription factor STIMPY and metabolic sugars as two interacting branches of the regulatory network that is responsible for activating meristematic tissue proliferation in Arabidopsis. In this study, we found that CYCP2;1 is both a direct target of STIMPY transcriptional activation and an early responder to sugar signals. Genetic and molecular studies show that CYCP2;1 physically interacts with three of the five mitotic CDKs in Arabidopsis, and is required for the G2 to M transition during meristem activation. Taken together, our results suggest that CYCP2;1 acts as a permissive control of cell cycle progression during seedling establishment by directly linking genetic control and nutritional cues with the activity of the core cell cycle machinery.

• Klíčová slova
• Arabidopsis, CYCP2;1, Cell division, Meristem, STIP, Sugar signal,
• MeSH
• aktivace transkripce MeSH
• Arabidopsis embryologie   MeSH
• buněčné dělení genetika   MeSH
• cyklin-dependentní kinasy biosyntéza   MeSH
• cykliny biosyntéza   genetika   metabolismus   MeSH
• homeodoménové proteiny genetika   MeSH
• meristém cytologie   embryologie   MeSH
• proliferace buněk MeSH
• proteiny huseníčku biosyntéza   genetika   metabolismus   MeSH
• regulace genové exprese u rostlin MeSH
• rostlinné geny MeSH
• sacharosa farmakologie   MeSH
• semenáček genetika   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, U.S. Gov't, Non-P.H.S. MeSH
• Názvy látek
• CDKB2;1 protein, Arabidopsis MeSH Prohlížeč
• CYCP2;1 protein, Arabidopsis MeSH Prohlížeč
• cyklin-dependentní kinasy MeSH
• cykliny MeSH
• D-type cyclin CDCD4.1, Arabidopsis MeSH Prohlížeč
• homeodoménové proteiny MeSH
• proteiny huseníčku MeSH
• sacharosa MeSH
• STIMPY protein, Arabidopsis MeSH Prohlížeč

The power spectrum was calculated for the time series of the LDE-type flare occurrence during the last three solar cycles (the 20-th, the 21-st and the first part of the 22-nd cycle). LDE-type flares (Long Duration Events in SXR) are associated with the interplanetary protons (SEP and STIP as well), energized coronal arches and radio type IV emission. Generally, in all the cycles considered, LDE-type flares mainly originated during a 6-year interval of the respective cycle (2 years before and 4 years after the sunspot cycle maximum). The following significant periodicities were found: in the 20-th cycle: 1.4, 2.1, 2.9, 4.0, 10.7 and 54.2 of month; in the 21-st cycle: 1.2, 1.6, 2.8, 4.9, 7.8 and 44.5 of month; in the 22-nd cycle, till March 1992: 1.4, 1.8, 2.4, 7.2, 8.7, 11.8 and 29.1 of month; in all interval (1969-1992): 1. the longer periodicities: 232.1, 121.1 (the dominant at 10.1 of year), 80.7, 61.9 and 25.6 of month, 2. the shorter periodicities: 4.7, 5.0, 6.8, 7.9, 9.1, 15.8 and 20.4 of month. Solar variability has an extremely complex time dependence. The Sun is a multiperiodic system. The strong periodicities "near 155 and 270 days" were found also in the LDE-type flare occurrence.

• MeSH
• elektrony * MeSH
• periodicita * MeSH
• protony * MeSH
• sluneční aktivita * MeSH
• spektroskopie infračervená s Fourierovou transformací MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• protony * MeSH

BACKGROUND: The Alternative DSM-5 Model for Personality Disorders and the latest eleventh version of the International Classification of Diseases implement the level of impairment in self and interpersonal personality functioning (Level of Personality Functioning Scale - LPFS) as a core feature of personality pathology. However, some studies have indicated that personality functioning is also impaired in other mental disorders, but a more thorough exploration is missing. Thus, this study aims to develop profiles of levels of personality functioning in people with personality disorders and some other psychiatric diagnoses as well as without diagnosis. METHODS: One-hundred-forty-nine people participated in the study. They came from three groups - healthy controls (n = 53), people with personality disorders (n = 58), and people with mood and anxiety disorders (n = 38). The LPFS was assessed by the Semi-structured Interview for Personality Functioning DSM-5 (STiP-5.1). An optimal clustering solution using agglomerative hierarchical cluster analysis was generated to represent profiles of personality functioning. RESULTS: The two patient groups showed significantly higher levels of personality functioning impairment than healthy controls. People with personality disorders showed higher levels of impairment than the other groups. In addition, the clustering analysis revealed three distinct profiles of personality functioning. CONCLUSIONS: The impairment of personality functioning seems to be useful in the clinical assessment of other than personality disorders as well. As the resulting clustering profiles suggest, LPFS can be seen as an overall indicator of the severity of mental health difficulties and the presence of mental disorders symptoms. The LPFS provides valuable and detailed information about the individual's mental health and can thus serve as a broad basis for case formulation, treatment and therapy planning, and prognosis.

• Klíčová slova
• anxiety disorders, mood disorders, personality disorders, personality functioning,
• MeSH
• Diagnostický a statistický manuál mentálních poruch MeSH
• lidé MeSH
• osobnost * MeSH
• poruchy osobnosti * diagnóza   MeSH
• psychometrie MeSH
• reprodukovatelnost výsledků MeSH
• shluková analýza MeSH
• úzkost MeSH
• úzkostné poruchy diagnóza   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH