Actinic keratosis (AK) is a characteristic skin lesion on skin areas of subjects with mainly phototype I and phototype II, or with specific genetic factors and who are exposed to prolonged ultraviolet radiation. AK may be considered a precursor of in situ squamous cell carcinoma (SCC), a type of non-melanoma skin cancer (NMSC). However, it is still not possible to predict which AK lesions will develop into SCC. Early treatment of AK is therefore recommended. Despite the increasing number of patients with AK developing into SCC, to date, there is still no clear suggestion of therapeutic strategy for AK. Current treatment consists of a multitude of topical lesion-directed or field-directed therapies or a combination of both. Recently, orally administered nicotinamide has shown to significantly reduce rates of new NMSC and AK in high-risk patients. This study aims to provide an update on the most relevant information about AK and to provide an insight into current and new treatment options.

• MeSH
• aktinická keratóza farmakoterapie   patologie   prevence a kontrola   MeSH
• lidé MeSH
• nádory kůže patologie   prevence a kontrola   MeSH
• niacinamid farmakologie   MeSH
• progrese nemoci MeSH
• spinocelulární karcinom patologie   prevence a kontrola   MeSH
• ultrafialové záření MeSH
• vitamin D aplikace a dávkování   farmakologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• niacinamid MeSH
• vitamin D MeSH