For preinvasive lesions of vulva, a common term VIN - vulval intraepithelial neoplasia is used. VIN is a histological dia-gnosis based on abnormal squamous epithelial proliferation. There are two types of VIN apart from their association with human papillomavirus (HPV). Undifferentiated (usual) vulval intraepithelial neoplasia is commonly associated with carcinogenic genotypes of HVP, whereas differentiated vulval intraepithelial neoplasia is not associated with high-risk genotypes of HPV. The article presents an overview of VIN occurence and epidemiology, its classification system and dia-gnostics. In conclusion, VIN therapeutical possibilities are presented. It can be treated with surgical therapy (local excision, partial vulvectomy, vulvectomy, laser vaporization) or medical therapy (imiquimod).

• Klíčová slova
• vulval intraepithelial neoplasia -  VIN -  epidemiology -  therapy,
• MeSH
• infekce papilomavirem klasifikace   diagnóza   epidemiologie   terapie   MeSH
• karcinom in situ klasifikace   diagnóza   epidemiologie   terapie   MeSH
• lidé MeSH
• nádory vulvy klasifikace   diagnóza   epidemiologie   terapie   MeSH
• prekancerózy MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH

OBJECTIVE: Case presentation, differential dia-gnostic, possible therapeutic procedure and a brief literature report. CASE REPORT: An 84-year-old woman was repeatedly examined for chronic extended dermatologic lesion on lower abdomen, external genitals, perianal region, groin and adjacent inner thighs. CONCLUSION: Neither colposcopy with dermatovenerologic consultation, nor histopathological examination led to a precise conclusion. Only a special dermatopathologic expertise showed a dia-gnosis of inverse psoriasis with suggested therapy.

• Klíčová slova
• Psoriasis, psoriasis, vulval lesion,
• MeSH
• lidé MeSH
• psoriáza * diagnóza   farmakoterapie   patologie   MeSH
• senioři nad 80 let MeSH
• vulva patologie   MeSH
• vulvitida * MeSH
• Check Tag
• lidé MeSH
• senioři nad 80 let MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

OBJECTIVE: Malignant melanoma of the vulva is the second commonest vulval malignancy. This article will focus on three cases of vulvar melanoma which have been solved surgically with wide excision, sentinel lymph node biopsy and radical lymphadenectomy. DESIGN: Case report. SETTING: Department of Dermatovenerology 3rd Faculty of Medicine, Charles University, Faculty Hospital Královské Vinohrady, Prague. METHODS: Biopsy of the lesion creates a reliable diagnostic procedure. More frequently digital dermoscopy is used for the precise primary diagnostics and follow-up of pigment vulvar lesions. RESULTS: Vulvar melanoma has been variously estimated to account for between 3.6 and 10% of malignant vulvar neoplasms. An epidemiologic study revealed ratio of vulvar to skin melanoma 1:71. CONCLUSION: New diagnostic methods such as digital dermoscopy or sentinel node biopsy bringing ever greater progress in precise diagnosis of patients with vulvar melanoma.

• MeSH
• biopsie sentinelové lymfatické uzliny MeSH
• biopsie MeSH
• dermatoskopie MeSH
• lidé MeSH
• lymfadenektomie MeSH
• melanom diagnóza   sekundární   chirurgie   MeSH
• mladiství MeSH
• mladý dospělý MeSH
• nádory vulvy patologie   chirurgie   MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH