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Aktivácia mikroglie v rôznych modelech poškodenia periférneho nervu [Microglia activation in different models of peripheral nerve injury]

S. Jergová, D. Čížková

. 2005 ; Roč. 9 (Suppl. 2) : s. 42-44.
. 2005 ; Roč. 9 (Suppl. 2) : s. 42-44.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc06013376

Pain and pain modulation has been viewed as being mediated solely by neurons. However, new research implicates spinal cord glia (microglia and astrocytes) as key players in the creation and maintenance of pathological pain. Sciatic nerve lesions are one of the most commonly studied pain-related injuries. In our study we aimed to characterize changes in microglia activation after axotomy and chronic constriction injury of the sciatic nerve of rats in the spinal cord and dorsal root ganglia (DRG) as well as to evaluate this activation in regard to pain behaviour in injured and sham groups of rats. Microglial activation was observed at the ipsilateral side of lumbar spinal cord as well as at L4–L6 DRG in all experimental groups. There were slight differences in the level and extent of microglia activation between nerve injury models used, however, differences were clear between nerve-injured and sham animals in accordance with different level of pain behaviour in these groups. It is known that activated microglia release various chemical mediators that can alter the function of neurons. Robust microglial activation observed in present study could contribute to pathological pain states observed following nerve injury. As neuropathic pain is by large not relieved by current therapies that target neurons, it is suggested that targeting glia might provide a novel approach for treatment of such unremitting pain conditions.

Microglia activation in different models of peripheral nerve injury

Aktivácia mikroglie v rôznych modelech poškodenia periférneho nervu = Microglia activation in different models of peripheral nerve injury : 12. Celostátní konference biologické psychiatrie "Teorie a praxe biologické psychiatrie". Luhačovice, 15.-18. června 2005. [Krátká sdělení] /

Microglia activation in different models of peripheral nerve injury : 12. Celostátní konference biologické psychiatrie "Teorie a praxe biologické psychiatrie". Luhačovice, 15.-18. června 2005. [Krátká sdělení]

Bibliografie atd.

Lit. 7

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