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The role of intrarenal angiotensin II in the development of hypertension in Ren-2 transgenic rats

Kopkan L, Kramer HJ, Husková Z, Vanourková Z, Skaroupková P, Thurmová M, Cervenka L.

. 2005 ; 23 (8) : 1531-1539.

Jazyk angličtina Země Velká Británie

Typ dokumentu srovnávací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc07507091

Grantová podpora
NR7956 MZ0 CEP - Centrální evidence projektů

E-zdroje Online

NLK Journals@Ovid Ovid Full Text od 1999-01-01 do 2010-02-01

OBJECTIVE: We investigated the responses of mean arterial pressure and renal blood flow to intravenous and intrarenal angiotensin II, plasma and kidney angiotensin II concentrations and renal angiotensin receptor subtype 1 protein expression, and renal functional responses to intravenous and intrarenal angiotensin receptor 1 blockade with candesartan. METHODS: In male anaesthetized transgenic rats and Hannover Sprague-Dawley rats aged 36-38 days mean arterial pressure and renal blood flow were determined after intravenous and intrarenal boluses of angiotensin II. Mean arterial pressure, renal blood flow and sodium excretion after intravenous or intrarenal candesartan were studied. Plasma and kidney angiotensin II concentrations were determined by radioimmunoassay. Renal angiotensin receptor subtype 1 protein levels were analysed by immunoblotting. RESULTS: The responses of mean arterial pressure and renal blood flow to angiotensin II were significantly greater in transgenic than in Hannover Sprague-Dawley rats. The administration of candesartan resulted in comparable decreases in mean arterial pressure and increases in renal blood flow and sodium excretion in both groups of rats. Renal angiotensin receptor subtype 1 protein levels were no different between Hannover Sprague-Dawley and transgenic rats. CONCLUSIONS: Plasma and kidney angiotensin II levels were lower in anaesthetized transgenic rats but, in contrast, were higher in decapitated transgenic rats when compared with Hannover Sprague-Dawley rats, suggesting that the kidney function of prehypertensive transgenic rats is under inappropriately high angiotensin II-dependent influence.

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