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TP53 gene mutations are rare in nondysplastic Barrett's esophagus
Novotna K, Trkova M, Pazdro A, Smejkal M, Soukupova A, Kodetova D, Smejkal P, Sedlacek Z.
Language English Country United States
Document type Comparative Study
NLK
ProQuest Central
from 1997-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1997-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-01-01 to 1 year ago
Family Health Database (ProQuest)
from 1997-01-01 to 1 year ago
- MeSH
- Adenocarcinoma genetics pathology MeSH
- Barrett Esophagus genetics pathology MeSH
- Biopsy MeSH
- DNA genetics MeSH
- Adult MeSH
- Exons MeSH
- Financing, Organized MeSH
- Genetic Markers MeSH
- Genes, p53 genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Mutation MeSH
- Esophageal Neoplasms genetics pathology MeSH
- Polymerase Chain Reaction MeSH
- Disease Progression MeSH
- Retrospective Studies MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
In search of potential prognostic markers, we analyzed a large series of tissues of Barrett's esophagus and samples of adenocarcinomas arising in the terrain of Barrett's esophagus for TP53 gene mutations by direct sequencing of exons 5 to 9 of the TP53 gene. While 9 of 21 adenocarcinomas tested (42.9%) contained a TP53 mutation, none of 24 samples from Barrett's esophagus were mutated. This observation suggests that TP53 gene mutation may be a relatively late event in the progression from nondysplastic Barrett's esophagus to adenocarcinoma of esophagus. Therefore, TP53 gene mutations alone are not likely to represent a widely useful prognostic marker of the risk of progression to malignancy, at least not in Barrett's esophagus without dysplasia.
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- $a Institute of Biology and Medical Genetics, Charles University Second Medical School, 15006, Prague 5, Czech Republic. kamila.novotna@lfmotol.cuni.cz
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- $a In search of potential prognostic markers, we analyzed a large series of tissues of Barrett's esophagus and samples of adenocarcinomas arising in the terrain of Barrett's esophagus for TP53 gene mutations by direct sequencing of exons 5 to 9 of the TP53 gene. While 9 of 21 adenocarcinomas tested (42.9%) contained a TP53 mutation, none of 24 samples from Barrett's esophagus were mutated. This observation suggests that TP53 gene mutation may be a relatively late event in the progression from nondysplastic Barrett's esophagus to adenocarcinoma of esophagus. Therefore, TP53 gene mutations alone are not likely to represent a widely useful prognostic marker of the risk of progression to malignancy, at least not in Barrett's esophagus without dysplasia.
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