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Resveratrol and its glycon piceid are stable polyphenols
Prokop J, Abrman P, Seligson AL, Sovak M.
Jazyk angličtina Země Spojené státy americké
- MeSH
- časové faktory MeSH
- fenoly chemie MeSH
- flavonoidy chemie MeSH
- glukosidy chemie MeSH
- ovoce chemie MeSH
- potravní doplňky MeSH
- rostlinné extrakty chemie MeSH
- stabilita léku MeSH
- stilbeny chemie MeSH
- Vitis chemie MeSH
- vysokoúčinná kapalinová chromatografie MeSH
Plant extracts containing phytopolyphenols, including resveratrol, are extensively used as nutraceutical supplements. Recent reports allege their lack of stability at ambient conditions. We have studied the stability of resveratrol and its glycon piceid in a mixture with a whole grape extract for 2 years (long-term stability) under Good Manufacturing Practice pharmaceutical protocols (at 60% humidity and 25 degrees C). The neat compounds were followed for 4 years under conditions of "accelerated stability," at 75% humidity and 40 degrees C, all in the presence of ambient air. Chromatographic analysis did not detect any instability, thus disproving the claims to the opposite. No storage precautions are necessary for these nutritional supplements.
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- $a Plant extracts containing phytopolyphenols, including resveratrol, are extensively used as nutraceutical supplements. Recent reports allege their lack of stability at ambient conditions. We have studied the stability of resveratrol and its glycon piceid in a mixture with a whole grape extract for 2 years (long-term stability) under Good Manufacturing Practice pharmaceutical protocols (at 60% humidity and 25 degrees C). The neat compounds were followed for 4 years under conditions of "accelerated stability," at 75% humidity and 40 degrees C, all in the presence of ambient air. Chromatographic analysis did not detect any instability, thus disproving the claims to the opposite. No storage precautions are necessary for these nutritional supplements.
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