Príspevok sa zaoberá skúmaním vplyvu bežne používaných humektantov glycerolu (GL) a propylénglykolu (PG) na liberáciu alaptidu (ALA) z 3% (m/m) chitosanových (CHIT) hydrogélov v porovnaní s liberáciou alaptidu (ALA) z krému. Obsah GL a PG v jednotlivých hydrogéloch bol 5 %, 10 %, 15 % (m/m). Alaptid je regeneračne pôsobiaci syntetický derivát prolyl-leucyl-glycin amidu, zatiaľ používaný vo veterinárnej medicíne. Jeho obsah v skúmaných hydrogéloch a kréme bol 1 % (m/m). Experimenty boli vykonané in vitro v temperovanej permeačnej aparatúre. Množstvo uvoľneného ALA bolo merané spektrofotometricky pri 212 nm, po 14. dňoch od prípravy jednotlivých chitosanových hydrogélov a krému. ALA sa uvoľnil v nasledovných množstvách: 14,06 % sa uvoľnilo z krému; 36,54 % z hydrogélu s obsahom 5 % GL (m/m); 37,85 % z hydrogélu s 5 % PG (m/m); 38,37 % z hydrogélu bez obsahu GL a PG; 40,71 % z hydrogélu s obsahom 15 % GL (m/m); 41,21 % z hydrogélu s 10 % GL (m/m); 42,72 % ALA sa uvoľnilo z hydrogélu s 10 % PG (m/m); 43,78 % z hydrogélu s 15 % PG (m/m). V závere možno usúdiť, že prítomnosť GL a PG malo vplyv na liberáciu ALA z dermálnych polotuhých liekov.

The paper examines the effects of routinely used humectants of glycerol (GL) and propylene glycol (PG) on the liberation of alaptid (ALA) from 3% (m/m) chitosan (CHIT) hydrogels in comparison with the liberation of alaptid (ALA) from cream. The contents of GL and PG in the individual hydrogels were 5%, 10%, 15% (m/m). Alaptid is a regeneratively acting synthetic derivative of prolyl-leucyl-glycin amide, which is for the time being used in veterinary medicine. Its content in the hydrogels and cream under study was 1% (m/m). The experiments were performed in vitro in a tempered permeating apparatus. The amount of the released ALA was measured spectrophotometrically at 212nm, 14 day after the preparation of the individual chitosan hydrogels and cream. ALA was liberated in the following amounts: 14.06% was released from cream; 36.54% from hydrogel containing 5% GL (m/m); 37.85% from hydrogel with 5% PG (m/m); 38.37% from hydrogel not containing GL and PG; 40.71% from hydrogel containing 15% GL (m/m); 41.21% from hydrogel with 10% GL (m/m); 42.72% ALA was released from hydrogel with 10% PG (m/m); 43.78% from hydrogel with 15% PG (m/m). It can be concluded that the presence of GL and PG exerted effects on liberation of ALA from dermal semisolid preparations.

Katedra galenickej farmácie Farmaceutická fakulta Univerzita Komenského Bratislava

Possible effects on the liberation of alaptid from dermal semisolid preparations

Lit.: 3