The influence of apolipoprotein E (ApoE) genotypes on plasma lipid levels and interaction with other environmental factors was determined in two Slovakian population samples; 146 Romany and 351 Slovak individuals. The two samples differ significantly in the distribution of E3/3 genotypes (p<0.014) and E3/2 (p<0.035). Analysis of variance did not reveal any significant effect of the ApoE genotypes on any of the plasma lipid levels in the Romany individuals. In the Slovak sample the variation in plasma low-density lipoprotein cholesterol (LDL-C) levels was significantly associated with the ApoE genotypes (p=0.012). We detected decreased LDL-C concentrations in males with E2 genotype when compared with E3 and E4 carriers (p=0.008). Further, the E2 genotype was found to be associated with high triglycerides levels (p=0.009). The ethnic samples differ significantly in the prevalence of metabolic syndrome and in the case of males of diabetes. Both the Romany and the Slovak males can be considered as having a more atherogenic profile compared with the females.

Department of Anthropology Faculty of Sciences Comenius University Bratislava Slovak Republic

000      

00000naa 2200000 a 4500

001      

bmc07522748

003      

CZ-PrNML

005      

20130109154538.0

008      

090507s2006 ci e eng||

009      

AR

040    __

$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a ci

100    1_

$a Siváková, Daniela, $d 1947- $7 xx0101769

245    10

$a Apolipoprotein E polymorphism in relation to plasma lipid levels and other risk factors of atherosclerosis in two ethnic groups from Slovakia / $c Siváková D, Zacharová M, Gasparovic J, Raslová K, Wsólová L, Basistová Z, Blazícek P.

314    __

$a Department of Anthropology, Faculty of Sciences, Comenius University, Bratislava, Slovak Republic. sivakova@fns.uniba.sk

520    9_

$a The influence of apolipoprotein E (ApoE) genotypes on plasma lipid levels and interaction with other environmental factors was determined in two Slovakian population samples; 146 Romany and 351 Slovak individuals. The two samples differ significantly in the distribution of E3/3 genotypes (p<0.014) and E3/2 (p<0.035). Analysis of variance did not reveal any significant effect of the ApoE genotypes on any of the plasma lipid levels in the Romany individuals. In the Slovak sample the variation in plasma low-density lipoprotein cholesterol (LDL-C) levels was significantly associated with the ApoE genotypes (p=0.012). We detected decreased LDL-C concentrations in males with E2 genotype when compared with E3 and E4 carriers (p=0.008). Further, the E2 genotype was found to be associated with high triglycerides levels (p=0.009). The ethnic samples differ significantly in the prevalence of metabolic syndrome and in the case of males of diabetes. Both the Romany and the Slovak males can be considered as having a more atherogenic profile compared with the females.

650    _2

$a dospělí $7 D000328

650    _2

$a apolipoproteiny E $x genetika $7 D001057

650    _2

$a ateroskleróza $x etnologie $x genetika $7 D050197

650    _2

$a cholesterol $x krev $7 D002784

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a frekvence genu $7 D005787

650    _2

$a genetická predispozice k nemoci $x etnologie $x genetika $7 D020022

650    _2

$a Romové $x etnologie $7 D006178

650    _2

$a lidé $7 D006801

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a lidé středního věku $7 D008875

650    _2

$a polymorfismus genetický $7 D011110

650    _2

$a regresní analýza $7 D012044

650    _2

$a rizikové faktory $7 D012307

650    _2

$a triglyceridy $x krev $7 D014280

651    _2

$a Slovenská republika $x epidemiologie $7 D018154

655    _2

$a multicentrická studie $7 D016448

700    1_

$a Zacharová, Maria

700    1_

$a Gasparovic, Juraj

700    1_

$a Rašlová, Katarína $7 xx0072890

700    1_

$a Wsolová, Ladislava

700    1_

$a Basistová, Zuzana

700    1_

$a Blažíček, Pavol $7 xx0077690

773    0_

$w MED00180201 $t Collegium antropologicum $g Roč. 30, č. 2 (2006), s. 387-394 $x 0350-6134

910    __

$a ABA008 $b x $y 9

990    __

$a 20090310084605 $b ABA008

991    __

$a 20130109154643 $b ABA008

999    __

$a ok $b bmc $g 650840 $s 504004

BAS    __

$a 3

BMC    __

$a 2006 $b 30 $c 2 $d 387-394 $m Collegium antropologicum $x MED00180201

LZP    __

$a 2009-B3/ipme