Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Apolipoprotein E polymorphism in relation to plasma lipid levels and other risk factors of atherosclerosis in two ethnic groups from Slovakia

Siváková D, Zacharová M, Gasparovic J, Raslová K, Wsólová L, Basistová Z, Blazícek P.

. 2006 ; 30 (2) : 387-394.

Language English Country Croatia

Document type Multicenter Study

Persistent link   https://www.medvik.cz/link/bmc07522748

The influence of apolipoprotein E (ApoE) genotypes on plasma lipid levels and interaction with other environmental factors was determined in two Slovakian population samples; 146 Romany and 351 Slovak individuals. The two samples differ significantly in the distribution of E3/3 genotypes (p<0.014) and E3/2 (p<0.035). Analysis of variance did not reveal any significant effect of the ApoE genotypes on any of the plasma lipid levels in the Romany individuals. In the Slovak sample the variation in plasma low-density lipoprotein cholesterol (LDL-C) levels was significantly associated with the ApoE genotypes (p=0.012). We detected decreased LDL-C concentrations in males with E2 genotype when compared with E3 and E4 carriers (p=0.008). Further, the E2 genotype was found to be associated with high triglycerides levels (p=0.009). The ethnic samples differ significantly in the prevalence of metabolic syndrome and in the case of males of diabetes. Both the Romany and the Slovak males can be considered as having a more atherogenic profile compared with the females.

000      
00000naa 2200000 a 4500
001      
bmc07522748
003      
CZ-PrNML
005      
20130109154538.0
008      
090507s2006 ci e eng||
009      
AR
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ci
100    1_
$a Siváková, Daniela, $d 1947- $7 xx0101769
245    10
$a Apolipoprotein E polymorphism in relation to plasma lipid levels and other risk factors of atherosclerosis in two ethnic groups from Slovakia / $c Siváková D, Zacharová M, Gasparovic J, Raslová K, Wsólová L, Basistová Z, Blazícek P.
314    __
$a Department of Anthropology, Faculty of Sciences, Comenius University, Bratislava, Slovak Republic. sivakova@fns.uniba.sk
520    9_
$a The influence of apolipoprotein E (ApoE) genotypes on plasma lipid levels and interaction with other environmental factors was determined in two Slovakian population samples; 146 Romany and 351 Slovak individuals. The two samples differ significantly in the distribution of E3/3 genotypes (p<0.014) and E3/2 (p<0.035). Analysis of variance did not reveal any significant effect of the ApoE genotypes on any of the plasma lipid levels in the Romany individuals. In the Slovak sample the variation in plasma low-density lipoprotein cholesterol (LDL-C) levels was significantly associated with the ApoE genotypes (p=0.012). We detected decreased LDL-C concentrations in males with E2 genotype when compared with E3 and E4 carriers (p=0.008). Further, the E2 genotype was found to be associated with high triglycerides levels (p=0.009). The ethnic samples differ significantly in the prevalence of metabolic syndrome and in the case of males of diabetes. Both the Romany and the Slovak males can be considered as having a more atherogenic profile compared with the females.
650    _2
$a dospělí $7 D000328
650    _2
$a apolipoproteiny E $x genetika $7 D001057
650    _2
$a ateroskleróza $x etnologie $x genetika $7 D050197
650    _2
$a cholesterol $x krev $7 D002784
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a frekvence genu $7 D005787
650    _2
$a genetická predispozice k nemoci $x etnologie $x genetika $7 D020022
650    _2
$a Romové $x etnologie $7 D006178
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a polymorfismus genetický $7 D011110
650    _2
$a regresní analýza $7 D012044
650    _2
$a rizikové faktory $7 D012307
650    _2
$a triglyceridy $x krev $7 D014280
651    _2
$a Slovenská republika $x epidemiologie $7 D018154
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Zacharová, Maria
700    1_
$a Gasparovic, Juraj
700    1_
$a Rašlová, Katarína $7 xx0072890
700    1_
$a Wsolová, Ladislava
700    1_
$a Basistová, Zuzana
700    1_
$a Blažíček, Pavol $7 xx0077690
773    0_
$w MED00180201 $t Collegium antropologicum $g Roč. 30, č. 2 (2006), s. 387-394 $x 0350-6134
910    __
$a ABA008 $b x $y 9
990    __
$a 20090310084605 $b ABA008
991    __
$a 20130109154643 $b ABA008
999    __
$a ok $b bmc $g 650840 $s 504004
BAS    __
$a 3
BMC    __
$a 2006 $b 30 $c 2 $d 387-394 $m Collegium antropologicum $x MED00180201
LZP    __
$a 2009-B3/ipme

Find record