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Je něco špatně v tomto záznamu ?
Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman: exists some reason for consideration?
Jana Zdarova Karasova, Jiri Bajgar, Ladislav Novotny, Kamil Kuca
Jazyk angličtina Země Česko
Typ dokumentu grafy a diagramy
NLK
Free Medical Journals
od 2003 do 2013
Freely Accessible Science Journals
od 2003 do 2013
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- acetylcholinesterasa metabolismus účinky léků MeSH
- experimenty na zvířatech MeSH
- financování organizované MeSH
- Huperzia škodlivé účinky toxicita MeSH
- organofosfáty škodlivé účinky toxicita MeSH
- potkani Wistar MeSH
- seskviterpeny aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- soman analogy a deriváty škodlivé účinky toxicita MeSH
- spektrofotometrie metody přístrojové vybavení využití MeSH
- statistika jako téma MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- grafy a diagramy MeSH
Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for, or is in a course of clinical trials for, the treatment of Alzheimer's disease. This compound has also been successfully tested for the pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in the central and also in the peripheral compartment. In this study Hup A in a higher dose (500 micro g/kg) was tested as a prophylaxis against a high, mainly centrally acting, nerve agent (soman). According to the results obtained, Hup A in this dosage was not able to protect AChE against soman in both the peripheral and central compartments. The effect of Hup A and soman was found to be additive and all animal subjects died.
Citace poskytuje Crossref.org
Lit.: 25
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- $a Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for, or is in a course of clinical trials for, the treatment of Alzheimer's disease. This compound has also been successfully tested for the pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in the central and also in the peripheral compartment. In this study Hup A in a higher dose (500 micro g/kg) was tested as a prophylaxis against a high, mainly centrally acting, nerve agent (soman). According to the results obtained, Hup A in this dosage was not able to protect AChE against soman in both the peripheral and central compartments. The effect of Hup A and soman was found to be additive and all animal subjects died.
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