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Changes of cholinesterase activities in the plasma and some tissues following administration of L-carnitine and galanthamine to rats
Bajgar J., Bartosova L., Fusek J., Svoboda Z., Herink J., Kvetina J., Palicka V., Zivny P., Blaha V.
Jazyk angličtina Země Irsko
Grantová podpora
NR7935
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- aktivace enzymů účinky léků MeSH
- butyrylcholinesterasa krev MeSH
- cholinesterasové inhibitory aplikace a dávkování MeSH
- cholinesterasy metabolismus MeSH
- financování organizované MeSH
- galantamin aplikace a dávkování MeSH
- karnitin aplikace a dávkování MeSH
- krysa rodu rattus MeSH
- lékové interakce MeSH
- lineární modely MeSH
- mozek účinky léků MeSH
- potkani Wistar MeSH
- vitamin B komplex aplikace a dávkování MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
Changes of acetylcholinesterase (AChE) activities in the hypophysis and brain (frontal cortex, hippocampus, medial septum and basal ganglia), and butyrylcholinesterase in plasma and liver following galanthamine (GAL) administration were studied in rats pretreated with L-carnitine (CAR). Following only GAL administration (10 mg/kg, i.m.), both cholinesterases (without clinical symptoms of GAL overdosage) were significantly inhibited. Pretreatment with CAR (3 consecutive days, 250 mg/kg, p.o.) followed by GAL administration showed higher AChE inhibition in comparison with single GAL administration. However, a statistically significant difference was observed for AChE in the hippocampus only. The activity of peripheral cholinesterases was not influenced by CAR pretreatment. Thus, pretreatment with CAR enhanced AChE inhibition in some brain parts of the rat following GAL administration.
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