-
Something wrong with this record ?
Changes of cholinesterase activities in the plasma and some tissues following administration of L-carnitine and galanthamine to rats
Bajgar J., Bartosova L., Fusek J., Svoboda Z., Herink J., Kvetina J., Palicka V., Zivny P., Blaha V.
Language English Country Ireland
Grant support
NR7935
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Enzyme Activation drug effects MeSH
- Butyrylcholinesterase blood MeSH
- Cholinesterase Inhibitors administration & dosage MeSH
- Cholinesterases metabolism MeSH
- Financing, Organized MeSH
- Galantamine administration & dosage MeSH
- Carnitine administration & dosage MeSH
- Rats MeSH
- Drug Interactions MeSH
- Linear Models MeSH
- Brain drug effects MeSH
- Rats, Wistar MeSH
- Vitamin B Complex administration & dosage MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
Changes of acetylcholinesterase (AChE) activities in the hypophysis and brain (frontal cortex, hippocampus, medial septum and basal ganglia), and butyrylcholinesterase in plasma and liver following galanthamine (GAL) administration were studied in rats pretreated with L-carnitine (CAR). Following only GAL administration (10 mg/kg, i.m.), both cholinesterases (without clinical symptoms of GAL overdosage) were significantly inhibited. Pretreatment with CAR (3 consecutive days, 250 mg/kg, p.o.) followed by GAL administration showed higher AChE inhibition in comparison with single GAL administration. However, a statistically significant difference was observed for AChE in the hippocampus only. The activity of peripheral cholinesterases was not influenced by CAR pretreatment. Thus, pretreatment with CAR enhanced AChE inhibition in some brain parts of the rat following GAL administration.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc09003762
- 003
- CZ-PrNML
- 005
- 20130913110236.0
- 008
- 091124s2007 ie e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ie
- 100 1_
- $a Bajgar, Jiří, $d 1944- $7 js20020122033
- 245 10
- $a Changes of cholinesterase activities in the plasma and some tissues following administration of L-carnitine and galanthamine to rats / $c Bajgar J., Bartosova L., Fusek J., Svoboda Z., Herink J., Kvetina J., Palicka V., Zivny P., Blaha V.
- 314 __
- $a Faculty of Military Health Sciences, University of Defence, and Institute of Clinical Biochemistry and Diagnostic, Faculty Hospital, Hradec Kralove, Czech Republic. bajgar@pmfhk.cz
- 520 9_
- $a Changes of acetylcholinesterase (AChE) activities in the hypophysis and brain (frontal cortex, hippocampus, medial septum and basal ganglia), and butyrylcholinesterase in plasma and liver following galanthamine (GAL) administration were studied in rats pretreated with L-carnitine (CAR). Following only GAL administration (10 mg/kg, i.m.), both cholinesterases (without clinical symptoms of GAL overdosage) were significantly inhibited. Pretreatment with CAR (3 consecutive days, 250 mg/kg, p.o.) followed by GAL administration showed higher AChE inhibition in comparison with single GAL administration. However, a statistically significant difference was observed for AChE in the hippocampus only. The activity of peripheral cholinesterases was not influenced by CAR pretreatment. Thus, pretreatment with CAR enhanced AChE inhibition in some brain parts of the rat following GAL administration.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a mozek $x účinky léků $7 D001921
- 650 _2
- $a butyrylcholinesterasa $x krev $7 D002091
- 650 _2
- $a karnitin $x aplikace a dávkování $7 D002331
- 650 _2
- $a cholinesterasové inhibitory $x aplikace a dávkování $7 D002800
- 650 _2
- $a cholinesterasy $x metabolismus $7 D002802
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a lékové interakce $7 D004347
- 650 _2
- $a aktivace enzymů $x účinky léků $7 D004789
- 650 _2
- $a galantamin $x aplikace a dávkování $7 D005702
- 650 _2
- $a lineární modely $7 D016014
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a potkani Wistar $7 D017208
- 650 _2
- $a vitamin B komplex $x aplikace a dávkování $7 D014803
- 700 1_
- $a Bartošová, Lucie, $d 1977- $7 xx0041840
- 700 1_
- $a Fusek, Josef, $d 1945- $7 nlk20000076283
- 700 1_
- $a Svoboda, Zbyněk $7 xx0081965
- 700 1_
- $a Herink, Josef, $d 1942- $7 jx20040423003
- 700 1_
- $a Květina, Jaroslav, $d 1930- $7 jk01071205
- 700 1_
- $a Palička, Vladimír, $d 1946- $7 jn99240000830
- 700 1_
- $a Živný, Pavel, $d 1961- $7 mzk2006324255
- 700 1_
- $a Bláha, Václav. $7 xx0194493
- 773 0_
- $w MED00003507 $t Neuroscience letters $g Roč. 411, č. 3 (2007), s. 212-216 $x 0304-3940
- 910 __
- $a ABA008 $b x $y 8
- 990 __
- $a 20091123115031 $b ABA008
- 991 __
- $a 20130913110734 $b ABA008
- 999 __
- $a ok $b bmc $g 696573 $s 558932
- BAS __
- $a 3
- BMC __
- $a 2007 $b 411 $c 3 $d 212-216 $i 0304-3940 $m Neuroscience letters $x MED00003507
- GRA __
- $a NR7935 $p MZ0
- LZP __
- $a 2009-B3/dkme
