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Tumor markers in pleural effusions
O. Topolčan, L. Holubec, V. Polívková, S. Svobodová, M. Pešek, V. Třeška, J. Šafránek, T. Hájek, L. Bartuněk, M. Roušarová, J. Fínek
Language English Country Greece
Grant support
NR9343
MZ0
CEP Register
NLK
Free Medical Journals
from 2004 to 2 years ago
Open Access Digital Library
from 2004-01-01
- MeSH
- CA-125 Antigen analysis MeSH
- CA-19-9 Antigen analysis MeSH
- Antigens, Neoplasm analysis MeSH
- Adult MeSH
- Financing, Organized MeSH
- Phosphopyruvate Hydratase analysis MeSH
- Calcitonin analysis MeSH
- Carcinoembryonic Antigen analysis MeSH
- Keratin-19 MeSH
- Keratins analysis MeSH
- Middle Aged MeSH
- Humans MeSH
- Mucin-1 analysis MeSH
- Biomarkers, Tumor analysis MeSH
- Neoplasms diagnosis MeSH
- Peptides analysis MeSH
- Pleural Effusion diagnosis chemistry MeSH
- Protein Precursors analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Thymidine Kinase analysis MeSH
- Tissue Polypeptide Antigen analysis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
AIM: The aim of this study was to determine the diagnostic capabilities of tumor markers in pleural effusion and their importance for assessment of the etiology of pleural effusions. PATIENTS AND METHODS: In pleural effusions from 166 patients hospitalized during the period 2003-2005 at the Department of Oncology and Radiotherapy, Faculty Hospital in Pilsen, the following tumor markers were determined: thymidine kinase (TK), neuron-specific enolase (NSE), cytokeratins [tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and cytokeratin fragment 19 (CYFRA 21-1)], carcinoembryonic antigen (CEA) and mucinous markers (CA 15-3, CA 19-9, CA 125). The inflammatory marker procalcitonin-PCT was also assessed. RESULTS: Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%. CONCLUSION: Significant positivity of PCT and CA 15-3 in pleural effusions indicate a suspicion of inflammatory disease. Positivity of TK and CA 15-3 indicate a strong suspicion of malignant exudates.
Charles University Prague 1st Medical Faculty Prague Czech Republic
Department of Surgery Charles University Medical School and Teaching Hospital Plzeň Czech Republic
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- $a Topolčan, Ondřej, $d 1943- $7 jn20000402383 $u Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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- $a Tumor markers in pleural effusions / $c O. Topolčan, L. Holubec, V. Polívková, S. Svobodová, M. Pešek, V. Třeška, J. Šafránek, T. Hájek, L. Bartuněk, M. Roušarová, J. Fínek
- 314 __
- $a Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzen, Czech Republic. topolcan@fnplzen.cz
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- $a AIM: The aim of this study was to determine the diagnostic capabilities of tumor markers in pleural effusion and their importance for assessment of the etiology of pleural effusions. PATIENTS AND METHODS: In pleural effusions from 166 patients hospitalized during the period 2003-2005 at the Department of Oncology and Radiotherapy, Faculty Hospital in Pilsen, the following tumor markers were determined: thymidine kinase (TK), neuron-specific enolase (NSE), cytokeratins [tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and cytokeratin fragment 19 (CYFRA 21-1)], carcinoembryonic antigen (CEA) and mucinous markers (CA 15-3, CA 19-9, CA 125). The inflammatory marker procalcitonin-PCT was also assessed. RESULTS: Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%. CONCLUSION: Significant positivity of PCT and CA 15-3 in pleural effusions indicate a suspicion of inflammatory disease. Positivity of TK and CA 15-3 indicate a strong suspicion of malignant exudates.
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- $a Holubec, Luboš, $d 1941- $7 skuk0003095 $u Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic; Department of Oncology and Radiotherapy, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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- $a Svobodová, Šárka $7 xx0104598 $u Charles University Prague, First Medical Faculty Prague, Czech Republic
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- $a Pešek, Miloš, $d 1950- $7 jn20021014008 $u Department of Pulmonary Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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- $a Třeška, Vladislav, $d 1957- $7 jn20000402436 $u Department of Surgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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- $a Šafránek, Jarmil, $d 1971- $7 xx0069521 $u Department of Surgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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- $a Hájek, Tomáš, $d 1962- $7 nlk20020123496 $u Department of Cardiosurgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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- $a Bartůněk, Lubomír $7 xx0106871 $u Department of Cardiosurgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
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