-
Je něco špatně v tomto záznamu ?
Tumor markers in pleural effusions
O. Topolčan, L. Holubec, V. Polívková, S. Svobodová, M. Pešek, V. Třeška, J. Šafránek, T. Hájek, L. Bartuněk, M. Roušarová, J. Fínek
Jazyk angličtina Země Řecko
Grantová podpora
NR9343
MZ0
CEP - Centrální evidence projektů
NLK
Free Medical Journals
od 2004 do Před 2 roky
Open Access Digital Library
od 2004-01-01
- MeSH
- antigen CA-125 analýza MeSH
- antigen CA-19-9 analýza MeSH
- antigeny nádorové analýza MeSH
- dospělí MeSH
- financování organizované MeSH
- fosfopyruváthydratasa analýza MeSH
- kalcitonin analýza MeSH
- karcinoembryonální antigen analýza MeSH
- keratin-19 MeSH
- keratiny analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- mucin 1 analýza MeSH
- nádorové biomarkery analýza MeSH
- nádory diagnóza MeSH
- peptidy analýza MeSH
- pleurální výpotek diagnóza chemie MeSH
- proteinové prekurzory analýza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- thymidinkináza analýza MeSH
- tkáňový polypeptidový antigen analýza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
AIM: The aim of this study was to determine the diagnostic capabilities of tumor markers in pleural effusion and their importance for assessment of the etiology of pleural effusions. PATIENTS AND METHODS: In pleural effusions from 166 patients hospitalized during the period 2003-2005 at the Department of Oncology and Radiotherapy, Faculty Hospital in Pilsen, the following tumor markers were determined: thymidine kinase (TK), neuron-specific enolase (NSE), cytokeratins [tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and cytokeratin fragment 19 (CYFRA 21-1)], carcinoembryonic antigen (CEA) and mucinous markers (CA 15-3, CA 19-9, CA 125). The inflammatory marker procalcitonin-PCT was also assessed. RESULTS: Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%. CONCLUSION: Significant positivity of PCT and CA 15-3 in pleural effusions indicate a suspicion of inflammatory disease. Positivity of TK and CA 15-3 indicate a strong suspicion of malignant exudates.
Charles University Prague 1st Medical Faculty Prague Czech Republic
Department of Surgery Charles University Medical School and Teaching Hospital Plzeň Czech Republic
- 000
- 00000naa 2200000 a 4500
- 001
- bmc10001066
- 003
- CZ-PrNML
- 005
- 20140714135133.0
- 008
- 100118s2007 gr e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gr
- 100 1_
- $a Topolčan, Ondřej, $d 1943- $7 jn20000402383 $u Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 245 10
- $a Tumor markers in pleural effusions / $c O. Topolčan, L. Holubec, V. Polívková, S. Svobodová, M. Pešek, V. Třeška, J. Šafránek, T. Hájek, L. Bartuněk, M. Roušarová, J. Fínek
- 314 __
- $a Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzen, Czech Republic. topolcan@fnplzen.cz
- 520 9_
- $a AIM: The aim of this study was to determine the diagnostic capabilities of tumor markers in pleural effusion and their importance for assessment of the etiology of pleural effusions. PATIENTS AND METHODS: In pleural effusions from 166 patients hospitalized during the period 2003-2005 at the Department of Oncology and Radiotherapy, Faculty Hospital in Pilsen, the following tumor markers were determined: thymidine kinase (TK), neuron-specific enolase (NSE), cytokeratins [tissue polypeptide antigen (TPA), tissue polypeptide-specific antigen (TPS) and cytokeratin fragment 19 (CYFRA 21-1)], carcinoembryonic antigen (CEA) and mucinous markers (CA 15-3, CA 19-9, CA 125). The inflammatory marker procalcitonin-PCT was also assessed. RESULTS: Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%. CONCLUSION: Significant positivity of PCT and CA 15-3 in pleural effusions indicate a suspicion of inflammatory disease. Positivity of TK and CA 15-3 indicate a strong suspicion of malignant exudates.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a antigeny nádorové $x analýza $7 D000951
- 650 _2
- $a antigen CA-125 $x analýza $7 D018394
- 650 _2
- $a antigen CA-19-9 $x analýza $7 D018395
- 650 _2
- $a kalcitonin $x analýza $7 D002116
- 650 _2
- $a karcinoembryonální antigen $x analýza $7 D002272
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a keratin-19 $7 D053539
- 650 _2
- $a keratiny $x analýza $7 D007633
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a mucin 1 $x analýza $7 D018396
- 650 _2
- $a nádory $x diagnóza $7 D009369
- 650 _2
- $a peptidy $x analýza $7 D010455
- 650 _2
- $a fosfopyruváthydratasa $x analýza $7 D010751
- 650 _2
- $a pleurální výpotek $x diagnóza $x chemie $7 D010996
- 650 _2
- $a proteinové prekurzory $x analýza $7 D011498
- 650 _2
- $a senzitivita a specificita $7 D012680
- 650 _2
- $a thymidinkináza $x analýza $7 D013937
- 650 _2
- $a tkáňový polypeptidový antigen $x analýza $7 D019396
- 650 _2
- $a nádorové biomarkery $x analýza $7 D014408
- 700 1_
- $a Holubec, Luboš, $d 1941- $7 skuk0003095 $u Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic; Department of Oncology and Radiotherapy, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Polívková, Vítězslava, $d 1944- $7 xx0073914 $u Department of Nuclear Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Svobodová, Šárka $7 xx0104598 $u Charles University Prague, First Medical Faculty Prague, Czech Republic
- 700 1_
- $a Pešek, Miloš, $d 1950- $7 jn20021014008 $u Department of Pulmonary Medicine, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Třeška, Vladislav, $d 1957- $7 jn20000402436 $u Department of Surgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Šafránek, Jarmil, $d 1971- $7 xx0069521 $u Department of Surgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Hájek, Tomáš, $d 1962- $7 nlk20020123496 $u Department of Cardiosurgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Bartůněk, Lubomír $7 xx0106871 $u Department of Cardiosurgery, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Roušarová, Milena. $7 jo2015860324 $u Department of Oncology and Radiotherapy, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 700 1_
- $a Fínek, Jindřich, $d 1957- $7 xx0026897 $u Department of Oncology and Radiotherapy, Charles University, Medical School and Teaching Hospital Plzeň, Czech Republic
- 773 0_
- $w MED00000478 $t Anticancer research $g Roč. 27, č. 4A (2007), s. 1921-1924 $x 0250-7005
- 910 __
- $a ABA008 $b x $y 8 $z 0
- 990 __
- $a 20100114083259 $b ABA008
- 991 __
- $a 20140714135431 $b ABA008
- 999 __
- $a ok $b bmc $g 704714 $s 567280
- BAS __
- $a 3
- BMC __
- $a 2007 $b 27 $c 4A $d 1921-1924 $i 0250-7005 $m Anticancer research $x MED00000478
- GRA __
- $a NR9343 $p MZ0
- LZP __
- $a 2010-b1/vtme
