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Stanovení tloušťky obalu tablet blízkou infračervenou spektroskopií
[Determination of the thickness of tablet coating by near-infrared spectroscopy]

Jan Muselík, Kateřina Krejčová, Miloslava Rabišková, Anna Bartošíková, Michaela Dračková, Lenka Vorlová

. 2010 ; 104 (1) : 41-45.

Language Czech Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc10008217

The aim of this study was to develop a fast and reliable method for determination of tablet coating thickness. Tablets were coated with polymeric Pharmacoat® 606 in a laboratory coater. The coating thickness was measured by near-IR absorption of the coating material using calibration. The calibration and validation results afforded the following parameters: determination coefficient R2 > 0.97, the number of factors 6 and the standard error of crossvalidation 5.4 ?m at the coating thickness 25–125 ?m. The obtained results confirmed suitability of the method for evaluation of coating quality.

Determination of the thickness of tablet coating by near-infrared spectroscopy

Bibliography, etc.

Lit.: 17

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$a Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita, Brno
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