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Expresie a lokalizácie kaspázy 1, superoxiddismutázy (D-mutázy) a kalretinínu v placente a bazálnej decidue pri preeklampsii
[Caspase 1, superoxiddismutase (D-mutase) and calretinin expression in the placenta and in the basal decidua in preeclampsia]
Jurkovič I., Böör A., Kočan P., Murín B.
Language Czech Country Czech Republic
- MeSH
- Decidua MeSH
- Financing, Organized MeSH
- Immunohistochemistry methods utilization MeSH
- Caspase 1 isolation & purification MeSH
- Clinical Laboratory Techniques utilization MeSH
- Humans MeSH
- Eye Proteins isolation & purification MeSH
- Placenta MeSH
- Pre-Eclampsia diagnosis MeSH
- Nerve Tissue Proteins isolation & purification MeSH
- S100 Calcium Binding Protein G isolation & purification MeSH
- Statistics as Topic MeSH
- Superoxide Dismutase isolation & purification MeSH
- Check Tag
- Humans MeSH
- Female MeSH
Ciel' ghansových bunkách, v jadrách endotelu fetálnych kapilár a v cytoplazme Hofbauerových buniek v obidvoch súboroch. Expresia v myofibroblastoch choriónovej strómy bola silnejšia v prípadoch preeklampsie. Expresia superoxiddismutázy dosahovala v materiáloch z preeklampsie slabšiu úroveň v syncýciu, Langhansových bunkách ako aj v bunkách deciduy. Kalretinín nevykázal expresiu v žiadnej štruktúre placenty. V bazálnej decidue z prípadov preeklampsie bol ojedinele prítomný v bunkách intersticiálneho extravilózneho trofoblastu, v deciduálnych bunkách a v špirálovitých artériách. Záver: Naše pozorovania sú morfologickým príspevkom do objasňovania molekulového pozadia etiopatogenézy preeklampsie a podporujú jej niektoré klinicko-biochemické rysy.
Objective: To determine new data related to the expression of caspase 1, superoxiddismutase and calretinin in the placenta and basal decidua in preeclampsia. Material and methods: Placental and basal decidua samples from 9 preeclamptic and 9 normotensive controls were analyzed using expressions of caspase 1, superoxiddismutase and calretinin assesed by immunohistochemistry. Results: Caspase 1 was expressed in placental syncythium in preeclampsia constantly, while in the control group the expression was weak or absent. In Langhans cells, in fetal sinusoidal capillary endothelia and in Hofbauer cells the expression was equal in both groups. Stronger expression was observed in stromal myofibroblasts in preeclampsia. In preeclampsia, expression of superoxiddismutase in syncythium, in Langhans cells and in decidual cells was weaker. Calretinin was not found in any placental structure. Sporadically, calretinin was expressed in the interstitial extravillous trophoblast cells, in decidual cells and in spiral arterioles in preeclampsia. Conclusion: The obtained morphological data correlating with some clinical and biochemical features contribute to understanding of the molecular background of preeclampsia etiopathogenesis.
Caspase 1, superoxiddismutase (D-mutase) and calretinin expression in the placenta and in the basal decidua in preeclampsia
Lit.: 47
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- $a Caspase 1, superoxiddismutase (D-mutase) and calretinin expression in the placenta and in the basal decidua in preeclampsia
- 314 __
- $a Ústav patológie, LF UPJŠ, Košice
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- $a Lit.: 47
- 520 3_
- $a Ciel' ghansových bunkách, v jadrách endotelu fetálnych kapilár a v cytoplazme Hofbauerových buniek v obidvoch súboroch. Expresia v myofibroblastoch choriónovej strómy bola silnejšia v prípadoch preeklampsie. Expresia superoxiddismutázy dosahovala v materiáloch z preeklampsie slabšiu úroveň v syncýciu, Langhansových bunkách ako aj v bunkách deciduy. Kalretinín nevykázal expresiu v žiadnej štruktúre placenty. V bazálnej decidue z prípadov preeklampsie bol ojedinele prítomný v bunkách intersticiálneho extravilózneho trofoblastu, v deciduálnych bunkách a v špirálovitých artériách. Záver: Naše pozorovania sú morfologickým príspevkom do objasňovania molekulového pozadia etiopatogenézy preeklampsie a podporujú jej niektoré klinicko-biochemické rysy.
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- $a Objective: To determine new data related to the expression of caspase 1, superoxiddismutase and calretinin in the placenta and basal decidua in preeclampsia. Material and methods: Placental and basal decidua samples from 9 preeclamptic and 9 normotensive controls were analyzed using expressions of caspase 1, superoxiddismutase and calretinin assesed by immunohistochemistry. Results: Caspase 1 was expressed in placental syncythium in preeclampsia constantly, while in the control group the expression was weak or absent. In Langhans cells, in fetal sinusoidal capillary endothelia and in Hofbauer cells the expression was equal in both groups. Stronger expression was observed in stromal myofibroblasts in preeclampsia. In preeclampsia, expression of superoxiddismutase in syncythium, in Langhans cells and in decidual cells was weaker. Calretinin was not found in any placental structure. Sporadically, calretinin was expressed in the interstitial extravillous trophoblast cells, in decidual cells and in spiral arterioles in preeclampsia. Conclusion: The obtained morphological data correlating with some clinical and biochemical features contribute to understanding of the molecular background of preeclampsia etiopathogenesis.
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