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Histological and ultrastructural changes of cardiomyocytes in experimental rats with tail thrombosis following subplantar application of carrageenin
R. Kod'ousek, J. Jezdinský, D. Krajčí
Jazyk angličtina Země Švýcarsko
Typ dokumentu srovnávací studie
E-zdroje NLK Online
Free Medical Journals od 1998 do Před 1 rokemKarger Journals od 1989 do 2009
Medline Complete (EBSCOhost) od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources od 1998
- MeSH
- karagenan aplikace a dávkování škodlivé účinky MeSH
- kardiomyocyty účinky léků ultrastruktura MeSH
- krysa rodu rattus MeSH
- modely nemocí na zvířatech MeSH
- nekróza MeSH
- ocas fyziologie patologie MeSH
- potkani Wistar MeSH
- trombóza chemicky indukované patologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- srovnávací studie MeSH
OBJECTIVE: To describe histological and ultrastructural changes of cardiomyocytes in experimental rats following subplantar administration of carrageenin. MATERIAL AND METHODS: In adult rats, an acute inflammatory reaction was induced by subplantar injection of 0.1 ml of 1% sterile carrageenin solution. In a total of 10 rats, which developed gangrene of tails in 5- to 12-cm-long segments, were killed and their internal organs fixed in 10% formaldehyde solution and subsequently processed for paraffin embedding. Later, blocks of the ventricular heart tissue were refixed and reprocessed for Araldite embedding and ultrastructure observation. Similarly, the cardiac muscle of control, carrageenin-injected rats which did not develop vascular thrombosis was processed. RESULTS: The cardiomyocytes of rats injected with carrageenin showed focal dystrophic alterations, enlarged mitochondria with densely packed concentrically oriented cristae, and many dense and irregularly shaped deposits with microgranular helicoid organization. Normal cardiomyocytes were observed in control rats. Complicating thrombosis of tail blood vessels leading to extensive tail necroses were also histologically confirmed. CONCLUSION: These findings demonstrate specific pathogenic effect in the cardiovascular system of the carrageenin-treated rats. 2007 S. Karger AG, Basel
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- $a OBJECTIVE: To describe histological and ultrastructural changes of cardiomyocytes in experimental rats following subplantar administration of carrageenin. MATERIAL AND METHODS: In adult rats, an acute inflammatory reaction was induced by subplantar injection of 0.1 ml of 1% sterile carrageenin solution. In a total of 10 rats, which developed gangrene of tails in 5- to 12-cm-long segments, were killed and their internal organs fixed in 10% formaldehyde solution and subsequently processed for paraffin embedding. Later, blocks of the ventricular heart tissue were refixed and reprocessed for Araldite embedding and ultrastructure observation. Similarly, the cardiac muscle of control, carrageenin-injected rats which did not develop vascular thrombosis was processed. RESULTS: The cardiomyocytes of rats injected with carrageenin showed focal dystrophic alterations, enlarged mitochondria with densely packed concentrically oriented cristae, and many dense and irregularly shaped deposits with microgranular helicoid organization. Normal cardiomyocytes were observed in control rats. Complicating thrombosis of tail blood vessels leading to extensive tail necroses were also histologically confirmed. CONCLUSION: These findings demonstrate specific pathogenic effect in the cardiovascular system of the carrageenin-treated rats. 2007 S. Karger AG, Basel
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