-
Je něco špatně v tomto záznamu ?
Interactions of antibiotics and extracts of Helichrysum pedunculatum against bacteria implicated in wound infections
Aiyegoro OA, Afolayan AJ, Okoh AI.
Jazyk angličtina Země Česko
- MeSH
- antibakteriální látky farmakologie MeSH
- Bacteria účinky léků MeSH
- financování organizované MeSH
- Helichrysum chemie MeSH
- infekce v ráně farmakoterapie mikrobiologie MeSH
- kombinovaná farmakoterapie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- rostlinné extrakty farmakologie MeSH
- synergismus léků MeSH
- Check Tag
- lidé MeSH
The effect of combinations of the crude acetone and aqueous extracts of Helichrysum pedunculatum leaves and eight antibiotics was determined by means of checkerboard and time-kill methods. In the checkerboard method, synergy of 45.8% was observed, being independent of Gram reaction, with combinations in the aqueous extract yielding largely (18.8%) antagonistic interactions. The time-kill assay detected synergy (45.8%) that was also independent of Gram reaction with a potentiation of more than 3 orders of the bactericidal activity of the test antibiotics. The crude leaf extracts of H. pedunculatum could thus be considered to be potential source of a broad-spectrum antibiotic-resistance-modifying compounds.
Citace poskytuje Crossref.org
Lit.: 24
- 000
- 00000naa 2200000 a 4500
- 001
- bmc10013079
- 003
- CZ-PrNML
- 005
- 20111210163635.0
- 008
- 101124s2010 xr e eng||
- 009
- AR
- 024 7_
- $a 10.1007/s12223-010-0026-5 $2 doi
- 035 __
- $a (PubMed)20490761
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Aiyegoro, O. A. $7 gn_A_00002756
- 245 10
- $a Interactions of antibiotics and extracts of Helichrysum pedunculatum against bacteria implicated in wound infections / $c Aiyegoro OA, Afolayan AJ, Okoh AI.
- 314 __
- $a Department of Biochemistry and Microbiology, University of Fort Hare, Alice
- 504 __
- $a Lit.: 24
- 520 9_
- $a The effect of combinations of the crude acetone and aqueous extracts of Helichrysum pedunculatum leaves and eight antibiotics was determined by means of checkerboard and time-kill methods. In the checkerboard method, synergy of 45.8% was observed, being independent of Gram reaction, with combinations in the aqueous extract yielding largely (18.8%) antagonistic interactions. The time-kill assay detected synergy (45.8%) that was also independent of Gram reaction with a potentiation of more than 3 orders of the bactericidal activity of the test antibiotics. The crude leaf extracts of H. pedunculatum could thus be considered to be potential source of a broad-spectrum antibiotic-resistance-modifying compounds.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a antibakteriální látky $x farmakologie $7 D000900
- 650 _2
- $a Bacteria $x účinky léků $7 D001419
- 650 _2
- $a synergismus léků $7 D004357
- 650 _2
- $a kombinovaná farmakoterapie $7 D004359
- 650 _2
- $a Helichrysum $x chemie $7 D036562
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mikrobiální testy citlivosti $7 D008826
- 650 _2
- $a rostlinné extrakty $x farmakologie $7 D010936
- 650 _2
- $a infekce v ráně $x farmakoterapie $x mikrobiologie $7 D014946
- 700 1_
- $a Afolayan, A. J. $7 gn_A_00002023
- 700 1_
- $a Okoh, A. I.
- 773 0_
- $w MED00011005 $t Folia microbiologica $g Roč. 55, č. 2 (2010), s. 176-180 $x 0015-5632
- 910 __
- $a ABA008 $b A 2403 $c 561 $y 8
- 990 __
- $a 20100531103706 $b ABA008
- 991 __
- $a 20101124151130 $b ABA008
- 999 __
- $a ok $b bmc $g 728671 $s 591865
- BAS __
- $a 3
- BMC __
- $a 2010 $b 55 $c 2 $d 176-180 $m Folia microbiologica $x MED00011005
- LZP __
- $a 2010-15/mkme
