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Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions
M. Novakova, V. Bruderova, Z. Sulova, J. Kopacek, L. Lacinova, R. Kvetnansky, A. Vasku, P. Kaplan, O. Krizanova, D. Jurkovicova
General physiology and biophysics.
2007 ;
26 (2) :
110-107.
Jazyk angličtina Země Slovensko
Perzistentní odkaz
https://www.medvik.cz/link/bmc10015027
- MeSH
- financování organizované MeSH
- hypoxie MeSH
- imobilizace MeSH
- inbrední kmeny myší MeSH
- inositol-1,4,5-trisfosfát - receptory metabolismus MeSH
- kardiomyocyty metabolismus patologie MeSH
- krysa rodu rattus MeSH
- kultivované buňky MeSH
- messenger RNA analýza MeSH
- myši MeSH
- potkani inbrední SHR MeSH
- regulace genové exprese MeSH
- RNA interference MeSH
- srdeční komory metabolismus patofyziologie MeSH
- terapeutická hypotermie MeSH
- věkové faktory MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptor's mRNA levels. Signalling cascade of sigma receptors is dependent on IP(3) receptors, since silencing of both, type 1 and 2 IP(3) receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.
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- $a Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions / $c M. Novakova, V. Bruderova, Z. Sulova, J. Kopacek, L. Lacinova, R. Kvetnansky, A. Vasku, P. Kaplan, O. Krizanova, D. Jurkovicova
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- $a Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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- $a The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptor's mRNA levels. Signalling cascade of sigma receptors is dependent on IP(3) receptors, since silencing of both, type 1 and 2 IP(3) receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.
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