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Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid
M Stiborova, E Frei, HH Schmeiser
Jazyk angličtina Země Spojené státy americké
Typ dokumentu komentáře
NLK
Free Medical Journals
od 1972 do 2011
Freely Accessible Science Journals
od 1972
ProQuest Central
od 2000-01-01 do 2015-12-31
Open Access Digital Library
od 1972-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do 2015-12-31
Health & Medicine (ProQuest)
od 2000-01-01 do 2015-12-31
PubMed
18480852
DOI
10.1038/ki.2008.125
Knihovny.cz E-zdroje
- MeSH
- játra enzymologie MeSH
- karcinogeny metabolismus toxicita MeSH
- kyseliny aristolochové metabolismus toxicita MeSH
- metabolická inaktivace MeSH
- myši MeSH
- NADPH-cytochrom c-reduktasa genetika metabolismus MeSH
- nemoci ledvin enzymologie chemicky indukované MeSH
- urologické nádory enzymologie chemicky indukované MeSH
- urotel MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- komentáře MeSH
Ingestion of aristolochic acid (AA) is associated with the development of AA-nephropathy and Balkan endemic nephropathy, which are characterized by chronic renal failure, tubulointerstitial fibrosis, and urothelial cancer. Understanding which enzymes are involved in AA activation and/or detoxification is important in assessing susceptibility to AA. Xiao et al. demonstrate that hepatic cytochrome P450s in mice detoxicate AA and thereby protect kidney from injury. The relative contribution of enzymes activating AA to induce urothelial cancer in humans remains to be resolved.
Citace poskytuje Crossref.org
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