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Glyoxalase I Glu111Ala polymorphism in patients with breast cancer
A. Germanová, A. Germanová, P. Tesařová, M. Jáchymová, K. Zvara, T. Zima, M. Kalousová
Language English Country Great Britain
Document type Research Support, Non-U.S. Gov't
NLK
Medline Complete (EBSCOhost)
from 2001-01-01 to 1 year ago
- MeSH
- Phenotype MeSH
- Gene Frequency MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Lactoylglutathione Lyase genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Breast Neoplasms enzymology genetics pathology MeSH
- Glycation End Products, Advanced blood MeSH
- Prognosis MeSH
- Receptors, Immunologic blood MeSH
- Receptors, Estrogen analysis MeSH
- Gene Expression Regulation, Enzymologic MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Higher frequency of the mutated C allele was found in patients with negative estrogen receptors and in patients in clinical stage III compared to controls (P< 0.05). The presence of the C allele could represent a negative prognostic factor; however, further studies are needed to confirm this hypothesis.
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