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Endoplasmic reticulum stress and apoptosis

J. Faitová, D. Krekáč, R. Hrstka, B. Vojtěšek

. 2006 ; 11 (4) : 488-505.

Jazyk angličtina Země Polsko

Typ dokumentu přehledy, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc11017399

Grantová podpora
NR8338 MZ0 CEP - Centrální evidence projektů

Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. In cells, the ER functions as the organelle where proteins mature, and as such, is very responsive to extracellular-intracellular changes of environment. This short overview focuses on the known pathways of programmed cell death triggering from or involving the ER.

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$a Department of Pathology and Experimental Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
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$a Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. In cells, the ER functions as the organelle where proteins mature, and as such, is very responsive to extracellular-intracellular changes of environment. This short overview focuses on the known pathways of programmed cell death triggering from or involving the ER.
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