Prezentovaný je leiomyóm gynekologického typu s obsahom amianthoid-like vlákien. Šlo o 6-centimetrový tumor maternice u 46-ročnej ženy. Histologicky obsahoval celulárnu populáciu hladkosvalových buniek, v ktorej boli početné eozinofilné amianthoid-like vlákna. Morfologicky tumor napodobňoval palisádovaný “amiantoidný” myofibroblastóm. Immunofenotyp tumoru bol hladkosvalový, s expresiou h-caldesmonu, desmínu, alfa hladkosvalového aktínu a s negativitou CD10 a S100 proteinu. Nález amianthoid-like vlákien rozširuje morfologické spektrum leiomyómov a demonštruje fenotypické prekrývanie leiomyómu a palisádovaného myofibroblastómu.

A rare case of a gynecologic type leiomyoma with amianthoid-like fibers is presented. The 6 cm tumor was found in the uterus of a 46-year-old woman. Histologically, it contained a cellular spindle cell population with numerous eosinophilic amianthoid-like fibers. The morphology closely resembled that of palisaded “amianthoid” myofibroblastoma. Immunohistochemically, the lesion showed a smooth muscle phenotype with expression of h-caldesmon, desmin, alpha smooth-muscle actin, and with negativity for CD10 and the S100 protein. The finding of amianthoid-like fibers expands the morphologic spectrum of leiomyomas. It represents one of the overlapping features between leiomyoma and palisaded myofibroblastoma.

Medicyt s r o Laboratory Trenčín Slovak Republic

Leiomyóm maternice s amianthoid-like vláknami

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