In order to have a better understanding of the classification, it is necessary to clarify the development of ectrodactyly. In order to do so, the authors reviewed papers and analysed their own clinical cases of ectrodactyly and conducted animal experiments to make different models of ectrodactyly. And they found that there should be at least four different types of teratogenic mechanisms of congenital defect of the digits. The first one is longitudinal deficiencies due to mesenchymal cell death in an early developmental stage; the second is abnormal induction of digital rays in the hand plate including cleft hand, central polydactyly and cleft hand. The third is constriction band syndrome, which is caused after digital radiations have been formed, and the fourth is transverse deficiency, in which the critical period is not known.

Center Sapporo Hand Surgery and Congenital Hand Differences Center Orthopaedic Hokushin higashi Hospital Sapporo

Teratogenní mechanismy vrozeného chybění prstů

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