-
Something wrong with this record ?
Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning
S. J. Somers, L. Lacerda, L. Opie, S. Lecour
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 1991
Free Medical Journals
from 1998
ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
from 2006-01-01
Nursing & Allied Health Database (ProQuest)
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Myocardial Infarction genetics pathology prevention & control MeSH
- Myocardial Ischemia genetics pathology prevention & control MeSH
- Ischemic Postconditioning MeSH
- Myocardium pathology MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- STAT3 Transcription Factor metabolism MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Postconditioning (PostC) is a recently discovered phenomenon whereby brief repetitive cycles of ischaemia with intermittent reperfusion following prolonged ischaemia elicit cardioprotection. This study investigated whether the age, genetic characteristics or number of repetitive cycles influenced the protective effect of PostC in mice. C57BL/6 floxed or non-floxed STAT-3 mice aged between 14-16 weeks (young) or 18-20 weeks (older) were perfused on a Langendorff apparatus and subjected to 35 min global ischaemia and 45 min reperfusion. PostC was elicited by either 3 (PostC-3) or 6 cycles (PostC-6) of 10s ischaemia and 10 s reperfusion. PostC-3 and PostC-6 in both young and older non-floxed mice reduced the myocardial infarct size. In contrast, only PostC-3 reduced myocardial infarct size in young floxed mice. Neither PostC-3 nor PostC-6 reduced the infarct in older floxed mice. Our data reveal that genetic characteristics, a minute difference in age or the number of postconditioning cycles are critical factors to be considered for the successful effect of ischaemic postconditioning in a murine model. Moreover, these factors should be taken into consideration for future experimental research or clinical applications of this protective phenomenon.
References provided by Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12006380
- 003
- CZ-PrNML
- 005
- 20120910114047.0
- 007
- ta
- 008
- 120229s2011 xr d f 000 0eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.932129 $2 doi
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Somers, S. J. $u Hatter Cardiovascular Research Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
- 245 10
- $a Age, genetic characteristics and number of cycles are critical factors to consider for successful protection of the murine heart with postconditioning / $c S. J. Somers, L. Lacerda, L. Opie, S. Lecour
- 504 __
- $a Literatura $b 13
- 520 9_
- $a Postconditioning (PostC) is a recently discovered phenomenon whereby brief repetitive cycles of ischaemia with intermittent reperfusion following prolonged ischaemia elicit cardioprotection. This study investigated whether the age, genetic characteristics or number of repetitive cycles influenced the protective effect of PostC in mice. C57BL/6 floxed or non-floxed STAT-3 mice aged between 14-16 weeks (young) or 18-20 weeks (older) were perfused on a Langendorff apparatus and subjected to 35 min global ischaemia and 45 min reperfusion. PostC was elicited by either 3 (PostC-3) or 6 cycles (PostC-6) of 10s ischaemia and 10 s reperfusion. PostC-3 and PostC-6 in both young and older non-floxed mice reduced the myocardial infarct size. In contrast, only PostC-3 reduced myocardial infarct size in young floxed mice. Neither PostC-3 nor PostC-6 reduced the infarct in older floxed mice. Our data reveal that genetic characteristics, a minute difference in age or the number of postconditioning cycles are critical factors to be considered for the successful effect of ischaemic postconditioning in a murine model. Moreover, these factors should be taken into consideration for future experimental research or clinical applications of this protective phenomenon.
- 650 02
- $a zvířata $7 D000818
- 650 02
- $a ischemický postconditioning $7 D057775
- 650 02
- $a mužské pohlaví $7 D008297
- 650 02
- $a myši $7 D051379
- 650 02
- $a myši inbrední C57BL $7 D008810
- 650 02
- $a infarkt myokardu $x genetika $x patologie $x prevence a kontrola $7 D009203
- 650 02
- $a ischemická choroba srdeční $x genetika $x patologie $x prevence a kontrola $7 D017202
- 650 02
- $a myokard $x patologie $7 D009206
- 650 02
- $a transkripční faktor STAT3 $x metabolismus $7 D050796
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Lacerda, L. $u Hatter Cardiovascular Research Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
- 700 1_
- $a Opie, L. $u Hatter Cardiovascular Research Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
- 700 1_
- $a Lecour, S. $u Hatter Cardiovascular Research Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
- 773 0_
- $t Physiological research $x 0862-8408 $g Roč. 60, č. 6 (2011), s. 971-974 $w MED00003824
- 910 __
- $a ABA008 $b A 4120 $c 266 $y 2
- 990 __
- $a 20120229072848 $b ABA008
- 991 __
- $a 20120910114221 $b ABA008
- 999 __
- $a ok $b bmc $g 899433 $s 763209
- BAS __
- $a 3
- BMC __
- $a 2011 $b 60 $c 6 $d 971-974 $i 0862-8408 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- LZP __
- $a 2012-12/ipme
