Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more

J. Kettner, Z. Dorazilová, I. Netuka, J. Malý, H. Al-Hiti, V. Melenovský, I. Skalský, H. Říha, I. Málek, J. Kautzner, J. Pirk

. 2011 ; 60 (5) : 769-775.

Language English Country Czech Republic

Document type Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12006465

Grant support
NS10497 MZ0 CEP Register

Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transplant candidates by means of ventricular assist device (VAD) implantation and subsequent OHTX. In 11 heart transplantation candidates with severe PH unresponsive to pharmacological intervention we implanted VAD with the aim of achieving PH to values acceptable for OHTX. In all patients we observed significant drop in pulmonary pressures, PVR and TPG (p<0.001 for all) 3 months after VAD implantation to values sufficient to allow OHTX. Seven patients underwent transplantation (mean duration of support 216 days) while none of patients suffered right-side heart failure in postoperative period. Two patients died after transplantation and five patients are living in very good condition with a mean duration of 286 days after OHTX. In our opinion, severe PH is not a contraindication for orthotopic heart transplantation any more.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc12006465
003      
CZ-PrNML
005      
20141009171827.0
007      
ta
008      
120301s2011 xr d f 000 0eng||
009      
AR
024    7_
$a 10.33549/physiolres.932158 $2 doi
040    __
$a ABA008 $d ABA008 $e AACR2 $b cze
041    0_
$a eng
044    __
$a xr
100    1_
$a Kettner, Jiří, $d 1956- $7 jo2003193175 $u Department of Cardiology, Institute for Clinical and Experimental Medicine – IKEM, Prague
245    10
$a Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more / $c J. Kettner, Z. Dorazilová, I. Netuka, J. Malý, H. Al-Hiti, V. Melenovský, I. Skalský, H. Říha, I. Málek, J. Kautzner, J. Pirk
504    __
$a Literatura $b 16
520    9_
$a Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transplant candidates by means of ventricular assist device (VAD) implantation and subsequent OHTX. In 11 heart transplantation candidates with severe PH unresponsive to pharmacological intervention we implanted VAD with the aim of achieving PH to values acceptable for OHTX. In all patients we observed significant drop in pulmonary pressures, PVR and TPG (p<0.001 for all) 3 months after VAD implantation to values sufficient to allow OHTX. Seven patients underwent transplantation (mean duration of support 216 days) while none of patients suffered right-side heart failure in postoperative period. Two patients died after transplantation and five patients are living in very good condition with a mean duration of 286 days after OHTX. In our opinion, severe PH is not a contraindication for orthotopic heart transplantation any more.
650    _2
$a kombinovaná terapie $7 D003131
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a srdeční selhání $x chirurgie $x komplikace $x patofyziologie $7 D006333
650    _2
$a transplantace srdce $x kontraindikace $7 D016027
650    _2
$a podpůrné srdeční systémy $7 D006353
650    _2
$a lidé $7 D006801
650    _2
$a plicní hypertenze $x etiologie $x patofyziologie $x prevence a kontrola $7 D006976
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a výsledek terapie $7 D016896
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Dorazilová, Zora $7 xx0075745 $u Department of Cardiology, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Netuka, Ivan, $d 1973- $7 xx0074183 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Malý, Jan, $d 1943-2021 $7 nlk19990073523 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Al-Hiti, Hikmet, $7 xx0073834 $u Department of Cardiology, Institute for Clinical and Experimental Medicine – IKEM, Prague $d 1970-
700    1_
$a Melenovský, Vojtěch $7 xx0160847 $u Department of Cardiology, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Skalský, Ivo $7 xx0097370 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Říha, Hynek. $7 xx0185812 $u Department of Anaesthesiology and Resuscitation, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Málek, Ivan, $d 1942- $7 nlk20030129885 $u Department of Cardiology, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Kautzner, Josef, $d 1957- $7 xx0037112 $u Department of Cardiology, Institute for Clinical and Experimental Medicine – IKEM, Prague
700    1_
$a Pirk, Jan, $d 1948- $7 nlk19990073700 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine – IKEM, Prague
773    0_
$t Physiological research $x 0862-8408 $g Roč. 60, č. 5 (2011), s. 769-775 $w MED00003824
910    __
$a ABA008 $b A 4120 $c 266 $y 2 $z 0
990    __
$a 20120229072848 $b ABA008
991    __
$a 20141009172216 $b ABA008
999    __
$a ok $b bmc $g 899523 $s 763296
BAS    __
$a 3
BMC    __
$a 2011 $b 60 $c 5 $d 769-775 $i 0862-8408 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NS10497 $p MZ0
LZP    __
$a 2012-12/ipme

Find record

Citation metrics

Archiving options