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Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants
DR. Barnes, MA. Rookus, L. McGuffog, G. Leslie, TM. Mooij, J. Dennis, N. Mavaddat, J. Adlard, M. Ahmed, K. Aittomäki, N. Andrieu, IL. Andrulis, N. Arnold, BK. Arun, J. Azzollini, J. Balmaña, RB. Barkardottir, D. Barrowdale, J. Benitez, P....
Language English Country United States
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
U10 CA180868
NCI NIH HHS - United States
UG1 CA189867
NCI NIH HHS - United States
11174
Cancer Research UK - United Kingdom
P30 CA008748
NCI NIH HHS - United States
P20 GM130423
NIGMS NIH HHS - United States
UG1 CA233191
NCI NIH HHS - United States
U10 CA180822
NCI NIH HHS - United States
203477/Z/16/Z
Wellcome Trust - United Kingdom
P30 CA016672
NCI NIH HHS - United States
NLK
ProQuest Central
from 2011-01-01 to 2021-12-31
Health & Medicine (ProQuest)
from 2011-01-01 to 2021-12-31
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Carcinoma, Ovarian Epithelial genetics MeSH
- Genetic Predisposition to Disease MeSH
- Heterozygote MeSH
- Humans MeSH
- Mutation MeSH
- Breast Neoplasms * epidemiology genetics MeSH
- Ovarian Neoplasms * epidemiology genetics MeSH
- Prospective Studies MeSH
- BRCA1 Protein genetics MeSH
- BRCA2 Protein genetics MeSH
- Retrospective Studies MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS: Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorphism (SNP) BC PRS were evaluated based on whether they predict overall, estrogen receptor (ER)-negative, or ER-positive BC, and two PRS for overall or high-grade serous EOC. Associations were validated in a prospective cohort. RESULTS: The ER-negative PRS showed the strongest association with BC risk for BRCA1 carriers (hazard ratio [HR] per standard deviation = 1.29 [95% CI 1.25-1.33], P = 3×10-72). For BRCA2, the strongest association was with overall BC PRS (HR = 1.31 [95% CI 1.27-1.36], P = 7×10-50). HR estimates decreased significantly with age and there was evidence for differences in associations by predicted variant effects on protein expression. The HR estimates were smaller than general population estimates. The high-grade serous PRS yielded the strongest associations with EOC risk for BRCA1 (HR = 1.32 [95% CI 1.25-1.40], P = 3×10-22) and BRCA2 (HR = 1.44 [95% CI 1.30-1.60], P = 4×10-12) carriers. The associations in the prospective cohort were similar. CONCLUSION: Population-based PRS are strongly associated with BC and EOC risks for BRCA1/2 carriers and predict substantial absolute risk differences for women at PRS distribution extremes.
Aalborg University Department of Clinical Medicine Aalborg Denmark
Aalborg University Hospital Clinical Cancer Research Center Aalborg Denmark
Aalborg University Hospital Molecular Diagnostics Aalborg Denmark
Aarhus University Hospital Department of Clinical Medicine Aarhus Denmark
Amsterdam UMC location AMC Department of Clinical Genetics Amsterdam The Netherlands
Amsterdam UMC location VUmc Department of Clinical Genetics Amsterdam The Netherlands
Beckman Research Institute of City of Hope Department of Population Sciences Duarte CA USA
Beth Israel Deaconess Medical Center Department of Medical Oncology Boston MA USA
Campus Virchov Klinikum Charite Institute of Human Genetics Berlin Germany
Cancer Council Victoria Cancer Epidemiology Division Melbourne VIC Australia
Cancer Genetics Centre Hong Kong Hereditary Breast Cancer Family Registry Happy Valley Hong Kong
Cancer Research Malaysia Breast Cancer Research Programme Subang Jaya Selangor Malaysia
Centre Antoine Lacassagne Département d'Hématologie Oncologie Médicale Nice France
Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK
Centre François Baclesse Département de Biopathologie Caen France
Centre Georges François Leclerc Unité d'oncogénétique Centre de Lutte Contre le Cancer Dijon France
Centre Léon Bérard Unité de Prévention et d'Epidémiologie Génétique Lyon France
Centro de Investigación en Red de Enfermedades Raras Madrid Spain
CH Niort Service Régional Oncogénétique Poitou Charentes Niort France
Chaim Sheba Medical Center The Susanne Levy Gertner Oncogenetics Unit Ramat Gan Israel
Chapel Allerton Hospital Yorkshire Regional Genetics Service Leeds UK
CHU de Besançon Service de Génétique Besançon France
CHU Nantes Laboratoire de genetique moleculaire Nantes France
CIBERONC Hospital Clinico San Carlos IdISSC Molecular Oncology Laboratory Madrid Spain
City of Hope Clinical Cancer Genomics Duarte CA USA
Columbia University Departments of Pediatrics and Medicine New York NY USA
Dana Farber Cancer Institute Cancer Risk and Prevention Clinic Boston MA USA
Department of Life and Health Sciences PSL University Paris France
DHU Dijon Centre de Génétique Dijon France
Fox Chase Cancer Center Department of Clinical Genetics Philadelphia PA USA
Fundación Pública Galega de Medicina Xenómica Santiago de Compostela Spain
German Cancer Research Center Molecular Genetics of Breast Cancer Heidelberg Germany
Ghent University Centre for Medical Genetics Ghent Belgium
Guy's and St Thomas' NHS Foundation Trust Clinical Genetics London UK
Hannover Medical School Institute of Human Genetics Hannover Germany
Hong Kong Sanatorium and Hospital Department of Surgery Happy Valley Hong Kong
Hospices Civils de Lyon Department of Genetics Bron France
Huntsman Cancer Institute Department of Medicine Salt Lake City UT USA
IDIBELL Catalan Institute of Oncology ProCURE Barcelona Spain
IEO European Institute of Oncology IRCCS Division of Cancer Prevention and Genetics Milan Italy
IFOM the FIRC Institute of Molecular Oncology Genome Diagnostics Program Milan Italy
INSERM U830 Department of Tumour Biology Paris France
Inserm U900 Genetic Epidemiology of Cancer team Paris France
Institut Curie Service de Génétique Paris France
Institut de Cancérologie Strasbourg Europe ICANS Strasbourg France
Karolinska Institutet Clinical Genetics Stockholm Sweden
Karolinska Institutet Department of Oncology Stockholm Sweden
Landspitali University Hospital Department of Pathology Reykjavik Iceland
Latvian Biomedical Research and Study Centre Riga Latvia
Leiden University Medical Center Department of Human Genetics Leiden The Netherlands
Leiden University Medical Center Department of Pathology Leiden The Netherlands
Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA
Lund University Division of Oncology and Pathology Department of Clinical Sciences Lund Lund Sweden
Lyon University UMR CNRS 5558 Lyon France
Maastricht University Medical Center Department of Clinical Genetics Maastricht The Netherlands
Magee Womens Hospital University of Pittsburgh School of Medicine Pittsburgh PA USA
Masaryk Memorial Cancer Institute Department of Cancer Epidemiology and Genetics Brno Czech Republic
Mayo Clinic Department of Laboratory Medicine and Pathology Rochester MN USA
Mayo Clinic Department of Oncology Rochester MN USA
Medical University of Vienna Dept of OB GYN and Comprehensive Cancer Center Vienna Austria
Medical University of Vienna Dept of OB GYN Vienna Austria
Mines ParisTech Fontainebleau France
N N Petrov Institute of Oncology St Petersburg Russia
National Institute of Oncology Department of Molecular Genetics Budapest Hungary
NHMRC Clinical Trials ANZ GOTG Coordinating Centre Camperdown NSW Australia
NorthShore University HealthSystem Center for Medical Genetics Evanston IL USA
Odense University Hospital Department of Clinical Genetics Odense Denmark
Oxford University Hospitals Oxford Centre for Genomic Medicine Oxford UK
Peter MacCallum Cancer Center Melbourne VIC Australia
Peter MacCallum Cancer Center Parkville Familial Cancer Centre Melbourne VIC Australia
Pomeranian Medical University Department of Genetics and Pathology Szczecin Poland
Portuguese Oncology Institute Department of Genetics Porto Portugal
Princess Anne Hospital Southampton UK
Queen Elizabeth University Hospitals Department of Clinical Genetics Glasgow UK
Radboud University Medical Center Department of Human Genetics Nijmegen The Netherlands
Region of Southern Denmark Vejle Hospital Department of Clinical Genetics Vejle Denmark
Rigshospitalet Copenhagen University Hospital Center for Genomic Medicine Copenhagen Denmark
Rigshospitalet Copenhagen University Hospital Department of Clinical Genetics Copenhagen Denmark
Rigshospitalet Copenhagen University Hospital Department of Oncology Copenhagen Denmark
Roswell Park Cancer Institute NRG Oncology Statistics and Data Management Center Buffalo NY USA
Royal Devon and Exeter Hospital Department of Clinical Genetics Exeter UK
Seoul National University Cancer Research Institute Seoul Korea
Seoul National University College of Medicine Department of Preventive Medicine Seoul Korea
Seoul National University Graduate School Department of Biomedical Sciences Seoul Korea
Sheffield Children's Hospital Sheffield Clinical Genetics Service Sheffield UK
Spanish National Cancer Research Centre Human Cancer Genetics Programme Madrid Spain
St George's NHS Foundation Trust Southwest Thames Regional Genetics Service London UK
State Research Institute Centre for Innovative Medicine Vilnius Lithuania
Tel Aviv University Sackler Faculty of Medicine Ramat Aviv Israel
The Institute of Cancer Research and Royal Marsden NHS Foundation Trust Oncogenetics Team London UK
The Kinghorn Cancer Centre Garvan Institute of Medical Research Sydney NSW Australia
The Netherlands Cancer Institute Department of Epidemiology Amsterdam The Netherlands
The Ohio State University Department of Cancer Biology and Genetics Columbus OH USA
The University of Chicago Center for Clinical Cancer Genetics Chicago IL USA
The University of Chicago Pritzker School of Medicine Chicago IL USA
The University of Hong Kong Department of Surgery Pok Fu Lam Hong Kong
The University of Melbourne Department of Clinical Pathology Melbourne VIC Australia
The University of Melbourne Department of Medicine St Vincent's Hospital Fitzroy VIC Australia
The University of Melbourne Sir Peter MacCallum Department of Oncology Melbourne VIC Australia
Unité d'Oncogénétique Centre de Lutte contre le Cancer Paul Strauss Strasbourg France
Université Paris Descartes Paris France
University Health Network Laboratory Medicine Program Toronto ON Canada
University Hospital Heidelberg Institute of Human Genetics Heidelberg Germany
University Hospital Leipzig Institute of Human Genetics Leipzig Germany
University Hospital of Vall d'Hebron Department of Medical Oncology Barcelona Spain
University Hospital SOD Genetica Molecolare Pisa Italy
University Hospital Ulm Department of Gynaecology and Obstetrics Ulm Germany
University Hospital Vall dHebron Clinical and Molecular Genetics Area Barcelona Spain
University Medical Center Utrecht Department of Medical Genetics Utrecht The Netherlands
University of California San Francisco Cancer Genetics and Prevention Program San Francisco CA USA
University of Helsinki Department of Clinical Genetics Helsinki University Hospital Helsinki Finland
University of Iceland BMC Faculty of Medicine Reykjavik Iceland
University of Leipzig Institute for Medical Informatics Statistics and Epidemiology Leipzig Germany
University of Malaya Department of Surgery Faculty of Medicine Kuala Lumpur Malaysia
University Of Melbourne Department of Medicine Melbourne VIC Australia
University of Munich Campus Großhadern Department of Gynecology and Obstetrics Munich Germany
University of Münster Institute of Human Genetics Münster Germany
University of NSW Sydney Adult Cancer Program Lowy Cancer Research Centre Sydney NSW Australia
University of Pennsylvania Basser Center for BRCA Abramson Cancer Center Philadelphia PA USA
University of Porto Biomedical Sciences Institute Porto Portugal
University of Pretoria Department of Genetics Arcadia South Africa
University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Houston TX USA
University of Toronto Department of Laboratory Medicine and Pathobiology Toronto ON Canada
University of Toronto Department of Molecular Genetics Toronto ON Canada
University Würzburg Department of Human Genetics Würzburg Germany
Vall d'Hebron Institute of Oncology High Risk and Cancer Prevention Group Barcelona Spain
Vall dHebron Institute of Oncology Oncogenetics Group Barcelona Spain
Veneto Institute of Oncology IOV IRCCS Immunology and Molecular Oncology Unit Padua Italy
Yale School of Medicine Chronic Disease Epidemiology New Haven CT USA
Zealand University Hospital Clinical Genetic Unit Department of Paediatrics Roskilde Denmark
References provided by Crossref.org
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- $a Barnes, Daniel R $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. drb54@medschl.cam.ac.uk
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- $a Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants / $c DR. Barnes, MA. Rookus, L. McGuffog, G. Leslie, TM. Mooij, J. Dennis, N. Mavaddat, J. Adlard, M. Ahmed, K. Aittomäki, N. Andrieu, IL. Andrulis, N. Arnold, BK. Arun, J. Azzollini, J. Balmaña, RB. Barkardottir, D. Barrowdale, J. Benitez, P. Berthet, K. Białkowska, AM. Blanco, MJ. Blok, B. Bonanni, SE. Boonen, Å. Borg, A. Bozsik, AR. Bradbury, P. Brennan, C. Brewer, J. Brunet, SS. Buys, T. Caldés, MA. Caligo, I. Campbell, LL. Christensen, WK. Chung, KBM. Claes, C. Colas, GEMO Study Collaborators, EMBRACE Collaborators, MA. Collonge-Rame, J. Cook, MB. Daly, R. Davidson, M. de la Hoya, R. de Putter, C. Delnatte, P. Devilee, O. Diez, YC. Ding, SM. Domchek, CM. Dorfling, M. Dumont, R. Eeles, B. Ejlertsen, C. Engel, DG. Evans, L. Faivre, L. Foretova, F. Fostira, M. Friedlander, E. Friedman, D. Frost, PA. Ganz, J. Garber, A. Gehrig, AM. Gerdes, P. Gesta, S. Giraud, G. Glendon, AK. Godwin, DE. Goldgar, A. González-Neira, MH. Greene, D. Gschwantler-Kaulich, E. Hahnen, U. Hamann, H. Hanson, J. Hentschel, FBL. Hogervorst, MJ. Hooning, J. Horvath, C. Hu, PJ. Hulick, EN. Imyanitov, kConFab Investigators, HEBON Investigators, GENEPSO Investigators, C. Isaacs, L. Izatt, A. Izquierdo, A. Jakubowska, PA. James, R. Janavicius, EM. John, V. Joseph, BY. Karlan, K. Kast, M. Koudijs, TA. Kruse, A. Kwong, Y. Laitman, C. Lasset, C. Lazaro, J. Lester, F. Lesueur, A. Liljegren, JT. Loud, J. Lubiński, PL. Mai, S. Manoukian, V. Mari, N. Mebirouk, HEJ. Meijers-Heijboer, A. Meindl, AR. Mensenkamp, A. Miller, M. Montagna, E. Mouret-Fourme, S. Mukherjee, AM. Mulligan, KL. Nathanson, SL. Neuhausen, H. Nevanlinna, D. Niederacher, FC. Nielsen, L. Nikitina-Zake, C. Noguès, E. Olah, OI. Olopade, KR. Ong, A. O'Shaughnessy-Kirwan, A. Osorio, CE. Ott, L. Papi, SK. Park, MT. Parsons, IS. Pedersen, B. Peissel, A. Peixoto, P. Peterlongo, G. Pfeiler, KA. Phillips, K. Prajzendanc, MA. Pujana, P. Radice, J. Ramser, SJ. Ramus, J. Rantala, G. Rennert, HA. Risch, M. Robson, K. Rønlund, R. Salani, H. Schuster, L. Senter, PD. Shah, P. Sharma, LE. Side, CF. Singer, TP. Slavin, P. Soucy, MC. Southey, AB. Spurdle, D. Steinemann, Z. Steinsnyder, D. Stoppa-Lyonnet, C. Sutter, YY. Tan, MR. Teixeira, SH. Teo, DL. Thull, M. Tischkowitz, S. Tognazzo, AE. Toland, AH. Trainer, N. Tung, K. van Engelen, EJ. van Rensburg, A. Vega, J. Vierstraete, G. Wagner, L. Walker, S. Wang-Gohrke, B. Wappenschmidt, JN. Weitzel, S. Yadav, X. Yang, D. Yannoukakos, D. Zimbalatti, K. Offit, M. Thomassen, FJ. Couch, RK. Schmutzler, J. Simard, DF. Easton, G. Chenevix-Trench, AC. Antoniou, Consortium of Investigators of Modifiers of BRCA and BRCA2
- 520 9_
- $a PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS: Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorphism (SNP) BC PRS were evaluated based on whether they predict overall, estrogen receptor (ER)-negative, or ER-positive BC, and two PRS for overall or high-grade serous EOC. Associations were validated in a prospective cohort. RESULTS: The ER-negative PRS showed the strongest association with BC risk for BRCA1 carriers (hazard ratio [HR] per standard deviation = 1.29 [95% CI 1.25-1.33], P = 3×10-72). For BRCA2, the strongest association was with overall BC PRS (HR = 1.31 [95% CI 1.27-1.36], P = 7×10-50). HR estimates decreased significantly with age and there was evidence for differences in associations by predicted variant effects on protein expression. The HR estimates were smaller than general population estimates. The high-grade serous PRS yielded the strongest associations with EOC risk for BRCA1 (HR = 1.32 [95% CI 1.25-1.40], P = 3×10-22) and BRCA2 (HR = 1.44 [95% CI 1.30-1.60], P = 4×10-12) carriers. The associations in the prospective cohort were similar. CONCLUSION: Population-based PRS are strongly associated with BC and EOC risks for BRCA1/2 carriers and predict substantial absolute risk differences for women at PRS distribution extremes.
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- 700 1_
- $a Garber, Judy $u Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA, USA
- 700 1_
- $a Gehrig, Andrea $u University Würzburg, Department of Human Genetics, Würzburg, Germany
- 700 1_
- $a Gerdes, Anne-Marie $u Rigshospitalet, Copenhagen University Hospital, Department of Clinical Genetics, Copenhagen, Denmark
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Goldgar, David E $u Huntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT, USA
- 700 1_
- $a González-Neira, Anna $u Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain
- 700 1_
- $a Greene, Mark H $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- 700 1_
- $a Gschwantler-Kaulich, Daphne $u Medical University of Vienna, Dept of OB/GYN, Vienna, Austria
- 700 1_
- $a Hahnen, Eric $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne, Germany $u Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany
- 700 1_
- $a Hamann, Ute $u German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Hu, Chunling $u Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA
- 700 1_
- $a Hulick, Peter J $u NorthShore University HealthSystem, Center for Medical Genetics, Evanston, IL, USA $u The University of Chicago Pritzker School of Medicine, Chicago, IL, USA
- 700 1_
- $a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia
- 700 1_
- $a Isaacs, Claudine $u Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
- 700 1_
- $a Izatt, Louise $u Guy's and St Thomas' NHS Foundation Trust, Clinical Genetics, London, UK
- 700 1_
- $a Izquierdo, Angel $u ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Hereditary Cancer Program, Barcelona, Spain
- 700 1_
- $a Jakubowska, Anna $u Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland $u Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland
- 700 1_
- $a James, Paul A $u The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia $u Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC, Australia
- 700 1_
- $a Janavicius, Ramunas $u Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania $u State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
- 700 1_
- $a John, Esther M $u Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, USA
- 700 1_
- $a Joseph, Vijai $u Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, USA
- 700 1_
- $a Karlan, Beth Y $u University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA $u Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA
- 700 1_
- $a Kast, Karin $u Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
- 700 1_
- $a Koudijs, Marco $u University Medical Center Utrecht, Department of Medical Genetics, Utrecht, The Netherlands
- 700 1_
- $a Kruse, Torben A $u Odense University Hospital, Department of Clinical Genetics, Odense, Denmark
- 700 1_
- $a Kwong, Ava $u Cancer Genetics Centre, Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong $u The University of Hong Kong, Department of Surgery, Pok Fu Lam, Hong Kong $u Hong Kong Sanatorium and Hospital, Department of Surgery, Happy Valley, Hong Kong
- 700 1_
- $a Laitman, Yael $u Chaim Sheba Medical Center, The Susanne Levy Gertner Oncogenetics Unit, Ramat Gan, Israel
- 700 1_
- $a Lasset, Christine $u Centre Léon Bérard, Unité de Prévention et d'Epidémiologie Génétique, Lyon, France $u Lyon University, UMR CNRS 5558, Lyon, France
- 700 1_
- $a Lazaro, Conxi $u ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Hereditary Cancer Program, Barcelona, Spain
- 700 1_
- $a Lester, Jenny $u University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA $u Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA
- 700 1_
- $a Lesueur, Fabienne $u Inserm U900, Genetic Epidemiology of Cancer team, Paris, France $u Institut Curie, Paris, France $u Mines ParisTech, Fontainebleau, France $u Department of Life & Health Sciences, PSL University, Paris, France
- 700 1_
- $a Liljegren, Annelie $u Karolinska Institutet, Department of Oncology, Stockholm, Sweden
- 700 1_
- $a Loud, Jennifer T $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- 700 1_
- $a Lubiński, Jan $u Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland
- 700 1_
- $a Mai, Phuong L $u Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
- 700 1_
- $a Manoukian, Siranoush $u Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy
- 700 1_
- $a Mari, Véronique $u Centre Antoine Lacassagne, Département d'Hématologie-Oncologie Médicale, Nice, France
- 700 1_
- $a Mebirouk, Noura $u Inserm U900, Genetic Epidemiology of Cancer team, Paris, France $u Institut Curie, Paris, France $u Mines ParisTech, Fontainebleau, France $u Department of Life & Health Sciences, PSL University, Paris, France
- 700 1_
- $a Meijers-Heijboer, Hanne E J $u Amsterdam UMC, location AMC, Department of Clinical Genetics, Amsterdam, The Netherlands
- 700 1_
- $a Meindl, Alfons $u University of Munich, Campus Großhadern, Department of Gynecology and Obstetrics, Munich, Germany
- 700 1_
- $a Mensenkamp, Arjen R $u Radboud University Medical Center, Department of Human Genetics, Nijmegen, The Netherlands
- 700 1_
- $a Miller, Austin $u Roswell Park Cancer Institute, NRG Oncology, Statistics and Data Management Center, Buffalo, NY, USA
- 700 1_
- $a Montagna, Marco $u Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy
- 700 1_
- $a Mouret-Fourme, Emmanuelle $u Institut Curie, Service de Génétique, Paris, France
- 700 1_
- $a Mukherjee, Semanti $u Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA
- 700 1_
- $a Mulligan, Anna Marie $u University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada $u University Health Network, Laboratory Medicine Program, Toronto, ON, Canada
- 700 1_
- $a Nathanson, Katherine L $u University of Pennsylvania, Basser Center for BRCA, Abramson Cancer Center, Philadelphia, PA, USA
- 700 1_
- $a Neuhausen, Susan L $u Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA
- 700 1_
- $a Nevanlinna, Heli $u University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland
- 700 1_
- $a Niederacher, Dieter $u University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Department of Gynecology and Obstetrics, Düsseldorf, Germany
- 700 1_
- $a Nielsen, Finn Cilius $u Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark
- 700 1_
- $a Nikitina-Zake, Liene $u Latvian Biomedical Research and Study Centre, Riga, Latvia
- 700 1_
- $a Noguès, Catherine $u Oncogénétique Clinique and Aix Marseille Univ, INSERM, IRD, SESSTIM, Institut Paoli-Calmettes, Département d'Anticipation et de Suivi des Cancers, Marseille, France
- 700 1_
- $a Olah, Edith $u National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary
- 700 1_
- $a Olopade, Olufunmilayo I $u The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL, USA
- 700 1_
- $a Ong, Kai-Ren $u Birmingham Women's Hospital Healthcare NHS Trust, West Midlands Regional Genetics Service, Birmingham, UK
- 700 1_
- $a O'Shaughnessy-Kirwan, Aoife $u Cambridge University Hospitals NHS Foundation Trust, East Anglian Medical Genetics Service, Cambridge, UK
- 700 1_
- $a Osorio, Ana $u Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain $u Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain
- 700 1_
- $a Ott, Claus-Eric $u Campus Virchov Klinikum, Charite, Institute of Human Genetics, Berlin, Germany
- 700 1_
- $a Papi, Laura $u University of Florence, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, Florence, Italy
- 700 1_
- $a Park, Sue K $u Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, Korea $u Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, Korea $u Seoul National University, Cancer Research Institute, Seoul, Korea
- 700 1_
- $a Parsons, Michael T $u QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia
- 700 1_
- $a Pedersen, Inge Sokilde $u Aalborg University Hospital, Molecular Diagnostics, Aalborg, Denmark $u Aalborg University Hospital, Clinical Cancer Research Center, Aalborg, Denmark $u Aalborg University, Department of Clinical Medicine, Aalborg, Denmark
- 700 1_
- $a Peissel, Bernard $u Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy
- 700 1_
- $a Peixoto, Ana $u Portuguese Oncology Institute, Department of Genetics, Porto, Portugal
- 700 1_
- $a Peterlongo, Paolo $u IFOM - the FIRC Institute of Molecular Oncology, Genome Diagnostics Program, Milan, Italy
- 700 1_
- $a Pfeiler, Georg $u Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria
- 700 1_
- $a Phillips, Kelly-Anne $u Peter MacCallum Cancer Center, Melbourne, VIC, Australia $u The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia $u The University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, VIC, Australia $u The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia
- 700 1_
- $a Prajzendanc, Karolina $u Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland
- 700 1_
- $a Pujana, Miquel Angel $u IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, ProCURE, Barcelona, Spain
- 700 1_
- $a Radice, Paolo $u Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy
- 700 1_
- $a Ramser, Juliane $u Klinikum rechts der Isar der Technischen Universität München, Department of Gynaecology and Obstetrics, Munich, Germany
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Robson, Mark $u Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Senter, Leigha $u The Ohio State University, Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, Columbus, OH, USA
- 700 1_
- $a Shah, Payal D $u Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA, USA
- 700 1_
- $a Sharma, Priyanka $u University of Kansas Medical Center, Department of Internal Medicine, Division of Medical Oncology, Westwood, KS, USA
- 700 1_
- $a Side, Lucy E $u Princess Anne Hospital, Southampton, UK
- 700 1_
- $a Singer, Christian F $u Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria
- 700 1_
- $a Slavin, Thomas P $u City of Hope, Clinical Cancer Genomics, Duarte, CA, USA
- 700 1_
- $a Soucy, Penny $u Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Genomics Center,, Québec City, QC, Canada
- 700 1_
- $a Southey, Melissa C $u Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia $u The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC, Australia $u Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia
- 700 1_
- $a Spurdle, Amanda B $u QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia
- 700 1_
- $a Steinemann, Doris $u Hannover Medical School, Institute of Human Genetics, Hannover, Germany
- 700 1_
- $a Steinsnyder, Zoe $u Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA
- 700 1_
- $a Stoppa-Lyonnet, Dominique $u Institut Curie, Service de Génétique, Paris, France $u INSERM U830, Department of Tumour Biology, Paris, France $u Université Paris Descartes, Paris, France
- 700 1_
- $a Sutter, Christian $u University Hospital Heidelberg, Institute of Human Genetics, Heidelberg, Germany
- 700 1_
- $a Tan, Yen Yen $u Medical University of Vienna, Dept of OB/GYN, Vienna, Austria
- 700 1_
- $a Teixeira, Manuel R $u Portuguese Oncology Institute, Department of Genetics, Porto, Portugal $u University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal
- 700 1_
- $a Teo, Soo Hwang $u Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, Malaysia $u University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, Malaysia
- 700 1_
- $a Thull, Darcy L $u Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA
- 700 1_
- $a Tischkowitz, Marc $u McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC, Canada $u University of Cambridge, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK
- 700 1_
- $a Tognazzo, Silvia $u Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy
- 700 1_
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- 700 1_
- $a Trainer, Alison H $u Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC, Australia $u University Of Melbourne, Department of Medicine, Melbourne, VIC, Australia
- 700 1_
- $a Tung, Nadine $u Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA, USA
- 700 1_
- $a van Engelen, Klaartje $u Amsterdam UMC, location VUmc, Department of Clinical Genetics, Amsterdam, The Netherlands
- 700 1_
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- 700 1_
- $a Vega, Ana $u Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain $u Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain $u Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain
- 700 1_
- $a Vierstraete, Jeroen $u Ghent University, Centre for Medical Genetics, Ghent, Belgium
- 700 1_
- $a Wagner, Gabriel $u Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria
- 700 1_
- $a Walker, Lisa $u Oxford University Hospitals, Oxford Centre for Genomic Medicine, Oxford, UK
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Yadav, Siddhartha $u Mayo Clinic, Department of Oncology, Rochester, MN, USA
- 700 1_
- $a Yang, Xin $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
- 700 1_
- $a Yannoukakos, Drakoulis $u National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece
- 700 1_
- $a Zimbalatti, Dario $u Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy
- 700 1_
- $a Offit, Kenneth $u Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, USA $u Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA
- 700 1_
- $a Thomassen, Mads $u Odense University Hospital, Department of Clinical Genetics, Odense, Denmark
- 700 1_
- $a Couch, Fergus J $u Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA
- 700 1_
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- 700 1_
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- 700 1_
- $a Easton, Douglas F $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK $u Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
- 700 1_
- $a Chenevix-Trench, Georgia $u QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia
- 700 1_
- $a Antoniou, Antonis C $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
- 710 2_
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- 710 2_
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- 710 2_
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