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Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction

L. F. Nurullin, A. R. Mukhitov, A. N. Tsentsevytsky, N. V. Petrova, D. V. Samigullin, A. I. Malomouzh, E. A. Bukharaeva, F. Vyskočil, E. E. Nikolsky

. 2011 ; 60 (5) : 815-823.

Language English Country Czech Republic

Document type Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12006484

It is well known that antagonists of N-type voltage-gated calcium channels inhibit the evoked quantal release of acetylcholine in amphibian neuromuscular synapses. This, however, does not exclude the functional expression of other types of voltage-gated calcium channels in these nerve terminals. Using immunocytochemistry, we detected the expression of the α1A subunit of P/Q-type calcium channels (that is otherwise typical of mammalian motor nerve endings) in the frog neuromuscular junction. In addition, we demonstrated that the P/Q-type channel blocker ω-agatoxin IVA (20 nM) reduced the action potentialinduced calcium transient and significantly decreased both spontaneous and evoked mediator release. Our data indicates the functional expression of P/Q-type calcium channels in the frog motor nerve ending which participate in acetylcholine release.

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