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Short-term antibiotics treatment in patients with nasal polyps and enterotoxins producing Staphylococcus aureus strains
P. Schalek, P. Petras, V. Klement, A. Hahn
Jazyk angličtina Země Německo
Typ dokumentu srovnávací studie, randomizované kontrolované studie
NLK
SpringerLink Journals
od 1997-01-01 do 2009-04-30
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
- MeSH
- antibakteriální látky aplikace a dávkování MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- endoskopie MeSH
- enterotoxiny imunologie sekrece MeSH
- imunoglobulin E imunologie MeSH
- infekce chirurgické rány farmakoterapie mikrobiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- nosní polypy chirurgie MeSH
- otorinolaryngologické chirurgické výkony metody MeSH
- pooperační péče metody MeSH
- prospektivní studie MeSH
- protilátky anti-idiotypické analýza MeSH
- rinitida farmakoterapie mikrobiologie MeSH
- rozvrh dávkování léků MeSH
- senioři MeSH
- Staphylococcus aureus izolace a purifikace metabolismus MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- randomizované kontrolované studie MeSH
- srovnávací studie MeSH
Enterotoxins produced by Staphylococcus aureus (SA) can act as super-antigens and thus influence the course of chronic rhinosinusitis with nasal polyps (NP). The aim of this study was to determine if antibiotic treatment administered after endoscopic sinus surgery (ESS) for NP can positively influence the course of the disease compared to placebo. After ESS, 23 patients who tested positive, in a perioperative culture, for SA strains producing enterotoxins A-E and TSST-1, were randomized into two groups. Group A which in addition to standard treatment received oral anti-staphylococcal antibiotics for 3 weeks. Group B received a placebo. Both groups were compared preoperatively, and at 3 and 6 months after surgery using a symptom-specific score, an endoscopic score and the SNOT-22 quality of life questionnaire. Slightly better results were achieved in patients who received antibiotic therapy. However, the differences were not statistically significant. Regardless of post-operative treatment, approximately 30% of patients had a SA-negative culture 6 months after surgery.
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- $a Enterotoxins produced by Staphylococcus aureus (SA) can act as super-antigens and thus influence the course of chronic rhinosinusitis with nasal polyps (NP). The aim of this study was to determine if antibiotic treatment administered after endoscopic sinus surgery (ESS) for NP can positively influence the course of the disease compared to placebo. After ESS, 23 patients who tested positive, in a perioperative culture, for SA strains producing enterotoxins A-E and TSST-1, were randomized into two groups. Group A which in addition to standard treatment received oral anti-staphylococcal antibiotics for 3 weeks. Group B received a placebo. Both groups were compared preoperatively, and at 3 and 6 months after surgery using a symptom-specific score, an endoscopic score and the SNOT-22 quality of life questionnaire. Slightly better results were achieved in patients who received antibiotic therapy. However, the differences were not statistically significant. Regardless of post-operative treatment, approximately 30% of patients had a SA-negative culture 6 months after surgery.
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