Organophosphorus compounds (OPCs) are a wide group of compounds both structurally and functionally. Each OPC has a unique toxicological profile. The exposure to this type of poison is not limited only to certain occupationally exposed people but also to children, women, pregnant women; all have chances to be exposed to this poison. During the recent past years it has been reported in many poison epidemiological studies and case reports that exposure of OPCs during pregnancy caused malformed fetuses, neural tube defect (NTD) and shortening of pregnancy. The literature for animal models reveals inconclusive evidence. The generalized view is that they are neither teratogenic nor embryotoxic. But it is not true. There is a lack of systematic study and scarcity of reports on the topic. The present study was undertaken to investigate the teratogenicity induced by organophosphorus compounds in different animal models by literature review. Literature was searched by Toxicology Data NetWork (TOXNET), Developmental and Reproductive Toxicology Database (DART), Toxicology Literature Online (TOXLINE), Hazardous Substances Data Bank (HSDB), Pubmed Central, Entrez-Pubmed, Science Direct, Directory Of Open Access Journal (DOAJ), Google Scholar and International Program on Chemical Safety (IPCS-INCHEM), Embase. The terms for literature search were teratogenicity, organophosphorus compounds; fetal toxicity, organophosphorus compounds; organophosphorus poisoning and pregnancy; organophosphorus poisoning and growth restriction; organophosphorus poisoning and IUGR; organophosphorus poisoning and reproduction; organophosphates and reproduction; pregnancy and organophosphates. The outcome of the study concludes that the work on teratogenicity induced by organophosphorus compounds was completely neglected, inconclusive, and only carried out on less than half of the OPCs available in the market. A more comprehensive and systemic study on the subject is clearly needed and its importance should not be ignored because more positive cases are being reported on the teratogenicity and embryotoxicity of OPCs.

Department of Pharmacology and Therapeutic Faculty of Medicine and Health Sciences UAE University AlAin

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