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Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?
L. Kren, K. Muckova, E. Lzicarova, M. Sova, V. Vybihal, T. Svoboda, P. Fadrus, M. Smrcka, O. Slaby, R. Lakomy, P. Vanhara, Z. Krenova, J. Michalek
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NS9875
MZ0
CEP Register
NS9871
MZ0
CEP Register
- MeSH
- Glioblastoma immunology physiopathology MeSH
- Gliosis immunology metabolism physiopathology MeSH
- HLA Antigens metabolism MeSH
- HLA-G Antigens MeSH
- Immunomodulation physiology MeSH
- Humans MeSH
- Macrophages immunology metabolism MeSH
- Cell Communication immunology MeSH
- Histocompatibility Antigens Class I metabolism MeSH
- Microglia immunology metabolism MeSH
- Brain immunology metabolism physiopathology MeSH
- Brain Neoplasms immunology physiopathology MeSH
- Cell Movement immunology MeSH
- Immunity, Innate immunology physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.
References provided by Crossref.org
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