• Je něco špatně v tomto záznamu ?

Structural and chemical aspects of HPMA copolymers as drug carriers

K. Ulbrich, V. Subr

. 2010 ; 62 (2) : 150-66.

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc12025999

Synthetic strategies and chemical and structural aspects of the synthesis of HPMA copolymer conjugates with various drugs and other biologically active molecules are described and discussed in this chapter. The discussion is held from the viewpoint of design and structure of the polymer backbone and biodegradable spacer between a polymer and drug, structure and methods of attachment of the employed drugs to the carrier and structure and methods of conjugation with targeting moieties. Physicochemical properties of the water-soluble polymer-drug conjugates and polymer micelles including mechanisms of drug release are also discussed. Detailed description of biological behavior of the polymer-drug conjugates as well as application of the copolymers for surface modification and targeting of gene delivery vectors are not included, they are presented and discussed in separate chapters of this issue.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12025999
003      
CZ-PrNML
005      
20130315202346.0
007      
ta
008      
120817s2010 ne f 000 0#eng||
009      
AR
024    7_
$a 10.1016/j.addr.2009.10.007 $2 doi
035    __
$a (PubMed)19931329
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Ulbrich, Karel, $d 1947- $7 jo2004259877 $u Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. ulbrich@imc.cas.cz
245    10
$a Structural and chemical aspects of HPMA copolymers as drug carriers / $c K. Ulbrich, V. Subr
520    9_
$a Synthetic strategies and chemical and structural aspects of the synthesis of HPMA copolymer conjugates with various drugs and other biologically active molecules are described and discussed in this chapter. The discussion is held from the viewpoint of design and structure of the polymer backbone and biodegradable spacer between a polymer and drug, structure and methods of attachment of the employed drugs to the carrier and structure and methods of conjugation with targeting moieties. Physicochemical properties of the water-soluble polymer-drug conjugates and polymer micelles including mechanisms of drug release are also discussed. Detailed description of biological behavior of the polymer-drug conjugates as well as application of the copolymers for surface modification and targeting of gene delivery vectors are not included, they are presented and discussed in separate chapters of this issue.
650    _2
$a akrylamidy $x aplikace a dávkování $x chemie $7 D000178
650    _2
$a zvířata $7 D000818
650    _2
$a nosiče léků $x aplikace a dávkování $x chemie $7 D004337
650    _2
$a systémy cílené aplikace léků $x metody $7 D016503
650    _2
$a lidé $7 D006801
650    _2
$a molekulární struktura $7 D015394
650    _2
$a polymery $x aplikace a dávkování $x chemie $7 D011108
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Šubr, Vladimír, $d 1957- $7 xx0088449
773    0_
$w MED00006623 $t Advanced drug delivery reviews $x 1872-8294 $g Roč. 62, č. 2 (2010), s. 150-66
856    41
$u https://pubmed.ncbi.nlm.nih.gov/19931329 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20130315202612 $b ABA008
999    __
$a ok $b bmc $g 948041 $s 783345
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2010 $b 62 $c 2 $d 150-66 $i 1872-8294 $m Advanced drug delivery reviews $n Adv Drug Deliv Rev $x MED00006623
LZP    __
$a Pubmed-20120817/10/03

Najít záznam

Citační ukazatele

    Možnosti archivace