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An electrophysiological study of visual processing in spinocerebellar ataxia type 2 (SCA2)
Jan Kremlacek, Martin Valis, Jiri Masopust, Ales Urban, Alena Zumrova, Radomir Talab, Miroslav Kuba, Zuzana Kubova, Jana Langrova
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NS10005
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
ProQuest Central
od 2002-03-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2002-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2002-03-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2002-03-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2002-03-01 do Před 1 rokem
- MeSH
- DNA genetika MeSH
- dospělí MeSH
- elektroencefalografie MeSH
- elektrofyziologické jevy MeSH
- evokované potenciály fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- neurologické vyšetření MeSH
- počítačové zpracování signálu MeSH
- rozpoznávání obrazu fyziologie MeSH
- senioři MeSH
- spinocerebelární ataxie genetika patofyziologie psychologie MeSH
- stárnutí fyziologie MeSH
- světelná stimulace MeSH
- trinukleotidové repetice MeSH
- věk při počátku nemoci MeSH
- zraková percepce fyziologie MeSH
- zrakové evokované potenciály fyziologie MeSH
- zrakové korové centrum patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Reports of visual functional impairment in spinocerebellar ataxia type 2 (SCA2) have been studied previously using pattern reversal visually evoked potentials (VEPs) with contradictory results. To provide additional evidence to this area, visual functions were studied using VEPs and event-related potentials (ERPs) in a group of ten patients with genetically verified SCA2. The electrophysiological examination included pattern reversal and motion-onset VEPs as well as visually driven oddball ERPs with an evaluation of a target and a pre-attentive response. In six patients, we found abnormal visual/cognitive processing that differed from normal values in latency, but not in the amplitude of the dominant VEP/ERP peaks. Among the VEPs/ERPs used, the motion-onset VEPs exhibited the highest sensitivity and showed a strong Spearman correlation to SCA2 duration (from r = 0.82 to r = 0.90, p < 0.001) and clinical state assessed by Brief Ataxia Rating Scale (from r = 0.71 (p = 0.022) to r = 0.80 (p < 0.001)). None of the VEP/ERP latencies showed a correlation to the triplet repeats of the SCA2 gene. In three patients, we did not find any visual/cognitive pathology, and one subject showed only a single subtle prolongation of the VEP peak. The observed visual/cognitive deficit was related to the subjects' clinical state and the illness duration, but no relationship to the genetic marker of SCA2 was found. From the VEP/ERP types used, the motion-onset VEPs seems to be the most promising candidate for clinical state monitoring rather than a tool for early diagnostic use.
Citace poskytuje Crossref.org
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