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Matrix metalloproteinases
O. Zitka, J. Kukacka, S. Krizkova, D. Huska, V. Adam, M. Masarik, R. Prusa, R. Kizek
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NS10200
MZ0
CEP - Centrální evidence projektů
- MeSH
- cystein metabolismus MeSH
- extracelulární matrix metabolismus MeSH
- inhibitory matrixových metaloproteinas MeSH
- kardiovaskulární nemoci farmakoterapie enzymologie patofyziologie MeSH
- lidé MeSH
- matrixové metaloproteinasy chemie genetika metabolismus MeSH
- nádory farmakoterapie enzymologie patofyziologie MeSH
- regulace genové exprese enzymů MeSH
- sloučeniny zinku chemie metabolismus farmakologie MeSH
- substrátová specifita MeSH
- tkáňové inhibitory metaloproteinas metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
Citace poskytuje Crossref.org
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- $a Zítka, Ondřej $7 xx0116134 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic.
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- $a Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
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