Matrix metalloproteinases
Language English Country United Arab Emirates Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
20846107
DOI
10.2174/092986710793213724
PII: BSP/CMC/E-Pub/242
Knihovny.cz E-resources
- MeSH
- Cysteine metabolism MeSH
- Extracellular Matrix metabolism MeSH
- Matrix Metalloproteinase Inhibitors MeSH
- Cardiovascular Diseases drug therapy enzymology physiopathology MeSH
- Humans MeSH
- Matrix Metalloproteinases chemistry genetics metabolism MeSH
- Neoplasms drug therapy enzymology physiopathology MeSH
- Gene Expression Regulation, Enzymologic MeSH
- Zinc Compounds chemistry metabolism pharmacology MeSH
- Substrate Specificity MeSH
- Tissue Inhibitor of Metalloproteinases metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Cysteine MeSH
- Matrix Metalloproteinase Inhibitors MeSH
- Matrix Metalloproteinases MeSH
- Zinc Compounds MeSH
- Tissue Inhibitor of Metalloproteinases MeSH
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
References provided by Crossref.org
The role of metallothionein in oxidative stress
