Matrix metalloproteinases
Jazyk angličtina Země Spojené arabské emiráty Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
20846107
DOI
10.2174/092986710793213724
PII: BSP/CMC/E-Pub/242
Knihovny.cz E-zdroje
- MeSH
- cystein metabolismus MeSH
- extracelulární matrix metabolismus MeSH
- inhibitory matrixových metaloproteinas MeSH
- kardiovaskulární nemoci farmakoterapie enzymologie patofyziologie MeSH
- lidé MeSH
- matrixové metaloproteinasy chemie genetika metabolismus MeSH
- nádory farmakoterapie enzymologie patofyziologie MeSH
- regulace genové exprese enzymů MeSH
- sloučeniny zinku chemie metabolismus farmakologie MeSH
- substrátová specifita MeSH
- tkáňové inhibitory metaloproteinas metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- cystein MeSH
- inhibitory matrixových metaloproteinas MeSH
- matrixové metaloproteinasy MeSH
- sloučeniny zinku MeSH
- tkáňové inhibitory metaloproteinas MeSH
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatin and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
Citace poskytuje Crossref.org
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