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Prognostic significance of increased urinary neopterin concentrations in patients with breast carcinoma

Hana Kalábová, Lenka Krčmová, Markéta Kašparová, Jiří Plíšek, Jan Laco, Radomír Hyšpler, H. Klozová, Dagmar Solichová, Bohuslav Melichar,

. 2011 ; 32 (5) : 525-529.

Language English Country Italy

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12028018

Grant support
NR9096 MZ0 CEP Register
NS10286 MZ0 CEP Register

Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with breast carcinoma are relatively innumerous. We have evaluated urinary neopterin in 456 patients with breast carcinoma. Urinary neopterin was determined using high-performance liquid chromatography. Neopterin in patients was increased only in a minority of patients with breast carcinoma. Increased urinary neopterin was associated with inferior overall survival. Prognostic significance of increased urinary neopterin was evident in patients with tumors expressing hormone receptors or/and human epidermal growth factor receptor (HER)-2, but not in patients with triple negative tumors. Among other parameters determined, C-reactive protein, hemoglobin, peripheral blood neutrophil count and platelet count were significant prognostic factors. On multivariate analysis, age, expression of hormone receptors, neutrophils, stage and hemoglobin concentration were independent prognostic indicators. In conclusion, serum neopterin is increased only in a minority of patients with breast carcinoma. Increased urinary neopterin was predictive of poor survival in univariate, but not multivariate analysis. Age, expression of hormone receptors, neutrophils, stage and hemoglobin concentration were independent prognostic indicators.

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$a Prognostic significance of increased urinary neopterin concentrations in patients with breast carcinoma / $c Hana Kalábová, Lenka Krčmová, Markéta Kašparová, Jiří Plíšek, Jan Laco, Radomír Hyšpler, H. Klozová, Dagmar Solichová, Bohuslav Melichar,
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$a Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with breast carcinoma are relatively innumerous. We have evaluated urinary neopterin in 456 patients with breast carcinoma. Urinary neopterin was determined using high-performance liquid chromatography. Neopterin in patients was increased only in a minority of patients with breast carcinoma. Increased urinary neopterin was associated with inferior overall survival. Prognostic significance of increased urinary neopterin was evident in patients with tumors expressing hormone receptors or/and human epidermal growth factor receptor (HER)-2, but not in patients with triple negative tumors. Among other parameters determined, C-reactive protein, hemoglobin, peripheral blood neutrophil count and platelet count were significant prognostic factors. On multivariate analysis, age, expression of hormone receptors, neutrophils, stage and hemoglobin concentration were independent prognostic indicators. In conclusion, serum neopterin is increased only in a minority of patients with breast carcinoma. Increased urinary neopterin was predictive of poor survival in univariate, but not multivariate analysis. Age, expression of hormone receptors, neutrophils, stage and hemoglobin concentration were independent prognostic indicators.
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$a Krčmová Kujovská, Lenka, $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic $d 1981- $7 xx0209338
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$a Kašparová, Markéta $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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$a Plíšek, Jiří $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic; Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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$a Laco, Jan $u Fingerland Institute of Pathology, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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$a Hyšpler, Radomír $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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$a Klozová, H.
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$a Solichová, Dagmar $u Department of Gerontology and Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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$a Melichar, Bohuslav $u Institute of Experimental Neurosurgery, Charles University Medichal School and Teaching Hospital, Hradec Králové, Czech Republic; Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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