-
Something wrong with this record ?
Using the pig's brain acetylcholinesterase immobilized on a textile fiber to test the antidotes of nerve agent poisonings – part I
Ivana Moravcova, Jiri Cabal, Jitka Sandova
Language English Country Czech Republic
Digital library NLK
Source
NLK
ROAD: Directory of Open Access Scholarly Resources
from 2011
- MeSH
- Acetylcholinesterase drug effects MeSH
- Antidotes therapeutic use MeSH
- Biosensing Techniques methods utilization MeSH
- Cell Culture Techniques utilization MeSH
- Chemical Warfare Agents adverse effects toxicity MeSH
- Brain enzymology MeSH
- Cholinesterase Reactivators therapeutic use MeSH
- Sus scrofa MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
An integral part of the research and development of new antidotes against nerve agents (herein referred to as NAs) is the verification of their efficacy by means of in vitro tests. The purpose of these tests is to verify the ability of an antidote to protect cholinesterases from inhibition or to reactivate inhibited cholinesterases. For this purpose cholinesterases of different species and with a different degree of purification are traditionally used. Using immobilized cholinesterases proves to be new and advantageous for a number of reasons. The authors of the presented work verified the usability of Detehit detector (Oritest Praha Ltd) containing the pig’s brain acetylcholinesterase for this purpose. In this article we see the results of tests focused on verifying the effect of different reaction conditions on the activity of acetylcholinesterase, especially with regard to reproducibility of these measurements.
References provided by Crossref.org
Obsahuje tabulky
Bibliography, etc.Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc12039308
- 003
- CZ-PrNML
- 005
- 20231023102409.0
- 007
- ta
- 008
- 121211s2012 xr d f 000 0eng||
- 009
- AR
- 024 7_
- $a 10.31482/mmsl.2012.019 $2 doi
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Moravcová, Ivana $7 xx0308805 $u 312th CBRN Defense Battalion, Liberec, Czech Republic
- 245 10
- $a Using the pig's brain acetylcholinesterase immobilized on a textile fiber to test the antidotes of nerve agent poisonings – part I / $c Ivana Moravcova, Jiri Cabal, Jitka Sandova
- 500 __
- $a Obsahuje tabulky
- 504 __
- $a Literatura $b 11
- 520 9_
- $a An integral part of the research and development of new antidotes against nerve agents (herein referred to as NAs) is the verification of their efficacy by means of in vitro tests. The purpose of these tests is to verify the ability of an antidote to protect cholinesterases from inhibition or to reactivate inhibited cholinesterases. For this purpose cholinesterases of different species and with a different degree of purification are traditionally used. Using immobilized cholinesterases proves to be new and advantageous for a number of reasons. The authors of the presented work verified the usability of Detehit detector (Oritest Praha Ltd) containing the pig’s brain acetylcholinesterase for this purpose. In this article we see the results of tests focused on verifying the effect of different reaction conditions on the activity of acetylcholinesterase, especially with regard to reproducibility of these measurements.
- 650 _2
- $a chemické bojové látky $x škodlivé účinky $x toxicita $7 D002619
- 650 _2
- $a antidota $x terapeutické užití $7 D000931
- 650 _2
- $a reaktivátory cholinesterasy $x terapeutické užití $7 D002801
- 650 _2
- $a acetylcholinesterasa $x účinky léků $7 D000110
- 650 _2
- $a buněčné kultury $x využití $7 D018929
- 650 _2
- $a mozek $x enzymologie $7 D001921
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a biosenzitivní techniky $x metody $x využití $7 D015374
- 650 _2
- $a Sus scrofa $7 D034421
- 650 _2
- $a techniky in vitro $7 D066298
- 700 1_
- $a Cabal, Jiří, $d 1957- $7 mzk2003181397 $u Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic
- 700 1_
- $a Šandová, Jitka. $7 _AN070332 $u 312th CBRN Defense Battalion, Liberec, Czech Republic
- 773 0_
- $t Vojenské zdravotnické listy $x 0372-7025 $g Roč. 81, č. 3 (2012), s. 129-137 $w MED00011116
- 910 __
- $a ABA008 $b A 3 $c 1073 $y 3 $z 0
- 990 __
- $a 20121211091215 $b ABA008
- 991 __
- $a 20231023102408 $b ABA008
- 999 __
- $a ok $b bmc $g 961392 $s 796887
- BAS __
- $a 3
- BMC __
- $a 2012 $b 81 $c 3 $d 129-137 $i 0372-7025 $m Vojenské zdravotnické listy $n Vojen. zdr. listy $x MED00011116
- LZP __
- $c NLK125 $d 20130124 $a NLK 2012-60/dk
