• Je něco špatně v tomto záznamu ?

Rapid HILIC method with fluorescence detection using derivatization reaction utilizing o-phthaldialdehyde for determination of degradation product of aliskiren

M. Douša, J. Břicháč, J. Svoboda, R. Klvaňa,

. 2012 ; 66 () : 359-64.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, validační studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc13000892

A rapid procedure based on direct extraction and HILIC separation of aliskiren (ALI) degradation product - 3-amino-2,2-dimethylpropanamide (ADPA) with fluorescence detection has been developed. The formation of ADPA from ALI under different conditions was studied. The evaluation of HILIC method robustness was performed using multifactorial experiments with fixed factors (one-level Plackett-Burman design). XBridge HILIC column with isocratic elution using mobile phase 10 mM K(2)HPO(4) pH 7.2-acetonitrile (26:74; v/v) was employed. Fluorescence detection after post column derivatization using o-phthaldialdehyde (OPA) reagent was performed at excitation and emission wavelength of 345 nm and 450 nm, respectively. The reported method has an advantage of a simple sample pre-treatment and quick and very sensitive measurement. The method was successfully applied for the analysis of commercially available ALI samples.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13000892
003      
CZ-PrNML
005      
20130110110208.0
007      
ta
008      
130108s2012 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.jpba.2012.03.015 $2 doi
035    __
$a (PubMed)22475518
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Douša, Michal $u Zentiva, a.s. Praha, U Kabelovny 130, 102 37 Praha 10, Czech Republic. hplc@hplc.cz
245    10
$a Rapid HILIC method with fluorescence detection using derivatization reaction utilizing o-phthaldialdehyde for determination of degradation product of aliskiren / $c M. Douša, J. Břicháč, J. Svoboda, R. Klvaňa,
520    9_
$a A rapid procedure based on direct extraction and HILIC separation of aliskiren (ALI) degradation product - 3-amino-2,2-dimethylpropanamide (ADPA) with fluorescence detection has been developed. The formation of ADPA from ALI under different conditions was studied. The evaluation of HILIC method robustness was performed using multifactorial experiments with fixed factors (one-level Plackett-Burman design). XBridge HILIC column with isocratic elution using mobile phase 10 mM K(2)HPO(4) pH 7.2-acetonitrile (26:74; v/v) was employed. Fluorescence detection after post column derivatization using o-phthaldialdehyde (OPA) reagent was performed at excitation and emission wavelength of 345 nm and 450 nm, respectively. The reported method has an advantage of a simple sample pre-treatment and quick and very sensitive measurement. The method was successfully applied for the analysis of commercially available ALI samples.
650    _2
$a amidy $x analýza $x chemie $7 D000577
650    _2
$a aminokyseliny $x analýza $7 D000596
650    _2
$a antihypertenziva $x analýza $x chemie $7 D000959
650    _2
$a chromatografie kapalinová $x metody $7 D002853
650    _2
$a fumaráty $x analýza $x chemie $7 D005650
650    _2
$a hmotnostní spektrometrie $x metody $7 D013058
650    _2
$a senzitivita a specificita $7 D012680
650    _2
$a fluorescenční spektrometrie $x metody $7 D013050
650    _2
$a časové faktory $7 D013997
650    _2
$a o-ftalaldehyd $x chemie $7 D009764
655    _2
$a časopisecké články $7 D016428
655    _2
$a validační studie $7 D023361
700    1_
$a Břicháč, Jiří
700    1_
$a Svoboda, Jiří
700    1_
$a Klvaňa, Robert
773    0_
$w MED00002894 $t Journal of pharmaceutical and biomedical analysis $x 1873-264X $g Roč. 66(2012), s. 359-64
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22475518 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130108 $b ABA008
991    __
$a 20130110110314 $b ABA008
999    __
$a ok $b bmc $g 963674 $s 799056
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 66 $d 359-64 $i 1873-264X $m Journal of pharmaceutical and biomedical analysis $n J Pharm Biomed Anal $x MED00002894
LZP    __
$a Pubmed-20130108

Najít záznam

Citační ukazatele

Možnosti archivace