Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia

S. Pospisilova, D. Gonzalez, J. Malcikova, M. Trbusek, D. Rossi, AP. Kater, F. Cymbalista, B. Eichhorst, M. Hallek, H. Döhner, P. Hillmen, M. van Oers, J. Gribben, P. Ghia, E. Montserrat, S. Stilgenbauer, T. Zenz

. 2012 ; 26 (7) : 1458-1461.

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc13000962

Grantová podpora
NS9858 MZ0 CEP - Centrální evidence projektů

Digitální knihovna NLK
Plný text - Článek
Zdroj

E-zdroje Online Plný text

NLK ProQuest Central od 2000-01-01 do Před 1 rokem
Open Access Digital Library od 1997-01-01
Medline Complete (EBSCOhost) od 1997-01-01 do 2015-11-30
Nursing & Allied Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem

Odkazy

PubMed 22297721
DOI 10.1038/leu.2012.25
Knihovny.cz E-zdroje

Recent evidence suggests that - in addition to 17p deletion - TP53 mutation is an independent prognostic factor in chronic lymphocytic leukemia (CLL). Data from retrospective analyses and prospective clinical trials show that ∼5% of untreated CLL patients with treatment indication have a TP53 mutation in the absence of 17p deletion. These patients have a poor response and reduced progression-free survival and overall survival with standard treatment approaches. These data suggest that TP53 mutation testing warrants integration into current diagnostic work up of patients with CLL. There are a number of assays to detect TP53 mutations, which have respective advantages and shortcomings. Direct Sanger sequencing of exons 4-9 can be recommended as a suitable test to identify TP53 mutations for centers with limited experience with alternative screening methods. Recommendations are provided on standard operating procedures, quality control, reporting and interpretation. Patients with treatment indications should be investigated for TP53 mutations in addition to the work-up recommended by the International workshop on CLL guidelines. Patients with TP53 mutation may be considered for allogeneic stem cell transplantation in first remission. Alemtuzumab-based regimens can yield a substantial proportion of complete responses, although of short duration. Ideally, patients should be treated within clinical trials exploring new therapeutic agents.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13000962
003      
CZ-PrNML
005      
20141222113924.0
007      
ta
008      
130108s2012 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/leu.2012.25 $2 doi
035    __
$a (PubMed)22297721
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Pospisilova, S. $u Central European Institute of Technology, Masaryk University, Czech Republic
245    10
$a ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia / $c S. Pospisilova, D. Gonzalez, J. Malcikova, M. Trbusek, D. Rossi, AP. Kater, F. Cymbalista, B. Eichhorst, M. Hallek, H. Döhner, P. Hillmen, M. van Oers, J. Gribben, P. Ghia, E. Montserrat, S. Stilgenbauer, T. Zenz
520    9_
$a Recent evidence suggests that - in addition to 17p deletion - TP53 mutation is an independent prognostic factor in chronic lymphocytic leukemia (CLL). Data from retrospective analyses and prospective clinical trials show that ∼5% of untreated CLL patients with treatment indication have a TP53 mutation in the absence of 17p deletion. These patients have a poor response and reduced progression-free survival and overall survival with standard treatment approaches. These data suggest that TP53 mutation testing warrants integration into current diagnostic work up of patients with CLL. There are a number of assays to detect TP53 mutations, which have respective advantages and shortcomings. Direct Sanger sequencing of exons 4-9 can be recommended as a suitable test to identify TP53 mutations for centers with limited experience with alternative screening methods. Recommendations are provided on standard operating procedures, quality control, reporting and interpretation. Patients with treatment indications should be investigated for TP53 mutations in addition to the work-up recommended by the International workshop on CLL guidelines. Patients with TP53 mutation may be considered for allogeneic stem cell transplantation in first remission. Alemtuzumab-based regimens can yield a substantial proportion of complete responses, although of short duration. Ideally, patients should be treated within clinical trials exploring new therapeutic agents.
650    _2
$a lidské chromozomy, pár 17 $x genetika $7 D002886
650    _2
$a lidé $7 D006801
650    _2
$a chronická lymfatická leukemie $x diagnóza $x genetika $x terapie $7 D015451
650    _2
$a mutace $x genetika $7 D009154
650    _2
$a směrnice pro lékařskou praxi jako téma $7 D017410
650    _2
$a prognóza $7 D011379
650    _2
$a nádorový supresorový protein p53 $x genetika $7 D016159
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Gonzalez, D. $u Division of Molecular Pathology, The Institute of Cancer Research, London, UK
700    1_
$a Malcikova, J. $u Central European Institute of Technology, Masaryk University, Czech Republic
700    1_
$a Trbusek, M. $u Central European Institute of Technology, Masaryk University, Czech Republic
700    1_
$a Rossi, D. $u Department of Translational Medicine, Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
700    1_
$a Kater, A. P. $u Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
700    1_
$a Cymbalista, F. $u Hôpital Avicenne, Université Paris XIII, Laboratoire d'hématologie, Bobigny, France
700    1_
$a Eichhorst, B. $u Department of Internal Medicine I, Center for Integrated Oncology Köln-Bonn, University of Cologne, Cologne, Germany
700    1_
$a Hallek, M. $u Department of Internal Medicine I, Center for Integrated Oncology Köln-Bonn, University of Cologne, Cologne, Germany
700    1_
$a Döhner, H. $u Department of Internal Medicine III, University of Ulm, Ulm, Germany
700    1_
$a Hillmen, P. $u Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds, UK
700    1_
$a van Oers, M. $u Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
700    1_
$a Gribben, J. $u Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
700    1_
$a Ghia, P. $u Laboratory of B-cell Neoplasia, Division of Molecular Oncology, San Raffaele Scientific Institute, Milan, Italy
700    1_
$a Montserrat, E. $u Department of Hematology, Institute of Hematology and Oncology, Hospital Clinic, Barcelona, IDIBAP, University of Barcelona, Barcelona, Spain
700    1_
$a Stilgenbauer, S. $u Department of Internal Medicine III, University of Ulm, Ulm, Germany
700    1_
$a Zenz, T. $u Department of Translational Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
773    0_
$w MED00003138 $t Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K $x 1476-5551 $g Roč. 26, č. 7 (2012), s. 1458-1461
856    41
$u https://pubmed.ncbi.nlm.nih.gov/22297721 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20130108 $b ABA008
991    __
$a 20141222113945 $b ABA008
999    __
$a ok $b bmc $g 963744 $s 799126
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2012 $b 26 $c 7 $d 1458-1461 $i 1476-5551 $m Leukemia $n Leukemia $x MED00003138
GRA    __
$a NS9858 $p MZ0
LZP    __
$a Pubmed-20130108

Najít záznam

Citační ukazatele

Možnosti archivace