Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

WWOX, a new potential tumor suppressor gene

R. Hezova, J. Ehrmann, Z. Kolar

. 2007 ; 151 (1) : 11-15.

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc13003647

Grant support
1A8244 MZ0 CEP Register

BACKGROUND: WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic. The aim of this study was to describe (i) putative protein interactions of WWOX (ii) the molecular mechanisms of tumor suppressor activity (iii) present an overview of WWOX in relation to nervous system and breast, prostate and ovarian cancers. METHODS AND RESULTS: WWOX expression is up-regulated in endocrine organs indicating its importance in these tissues. In many cancers WWOX expression is down-regulated and low WWOX expression is related to poor prognosis. CONCLUSION: All the evidence suggest that WWOX can be considered as a new tumor suppressor gene and target for gene therapy due to the association of high WWOX expression with improved disease free survival.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc13003647
003      
CZ-PrNML
005      
20130814075825.0
007      
ta
008      
130128s2007 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2007.002 $2 doi
035    __
$a (PubMed)17690733
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Héžová, Renata $7 xx0157096 $u Department of Pathology & Laboratory of Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc
245    10
$a WWOX, a new potential tumor suppressor gene / $c R. Hezova, J. Ehrmann, Z. Kolar
520    9_
$a BACKGROUND: WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic. The aim of this study was to describe (i) putative protein interactions of WWOX (ii) the molecular mechanisms of tumor suppressor activity (iii) present an overview of WWOX in relation to nervous system and breast, prostate and ovarian cancers. METHODS AND RESULTS: WWOX expression is up-regulated in endocrine organs indicating its importance in these tissues. In many cancers WWOX expression is down-regulated and low WWOX expression is related to poor prognosis. CONCLUSION: All the evidence suggest that WWOX can be considered as a new tumor suppressor gene and target for gene therapy due to the association of high WWOX expression with improved disease free survival.
650    _2
$a zvířata $7 D000818
650    _2
$a nádory prsu $x genetika $7 D001943
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a exprese genu $7 D015870
650    _2
$a tumor supresorové geny $7 D016147
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a nádory $x genetika $7 D009369
650    _2
$a nádory vaječníků $x genetika $7 D010051
650    _2
$a oxidoreduktasy $x genetika $7 D010088
650    _2
$a nádory prostaty $x genetika $7 D011471
650    _2
$a nádorové supresorové proteiny $x genetika $7 D025521
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Ehrmann, Jiří, $d 1967- $7 jo2003163162 $u Department of Pathology & Laboratory of Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc
700    1_
$a Kolář, Zdeněk, $d 1953- $7 jn20000710256 $u Department of Pathology & Laboratory of Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Olomouc
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic $x 1213-8118 $g Roč. 151, č. 1 (2007), s. 11-15
910    __
$a ABA008 $b A 1502 $c sign $y 3 $z 0
990    __
$a 20130128 $b ABA008
991    __
$a 20130814080334 $b ABA008
999    __
$a ok $b bmc $g 966303 $s 801842
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2007 $b 151 $c 1 $d 11-15 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
GRA    __
$a 1A8244 $p MZ0
LZP    __
$b NLK111 $a Pubmed-20130128

Find record

Citation metrics

Archiving options