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Development of ciprofloxacin resistance due to chromosomal mutations induced by 2-nitrofluorene
L. Birosová, M. Mikulásová
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2001
Free Medical Journals
from 1998
ROAD: Directory of Open Access Scholarly Resources
from 2001
PubMed
16601798
DOI
10.5507/bp.2005.068
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents pharmacology MeSH
- Genes, Bacterial drug effects MeSH
- Drug Resistance, Bacterial genetics MeSH
- Ciprofloxacin pharmacology MeSH
- Fluorenes pharmacology MeSH
- Mutation drug effects MeSH
- Salmonella typhimurium drug effects genetics MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.
References provided by Crossref.org
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