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Activity of thrombocytes as a marker of sufficient intensity of LDL-apheresis in familial hypercholesterolaemia
M Blaha, M Pecka, J Urbankova, V Blaha, J Maly, Z Zadak, M Blazek
Jazyk angličtina Země Velká Británie
Grantová podpora
NB6549
MZ0
CEP - Centrální evidence projektů
NR8036
MZ0
CEP - Centrální evidence projektů
- MeSH
- adenosindifosfát chemie MeSH
- agregace trombocytů MeSH
- aktivace trombocytů MeSH
- časové faktory MeSH
- cholesterol metabolismus MeSH
- heterozygot MeSH
- homozygot MeSH
- hyperlipoproteinemie typ II * metabolismus MeSH
- LDL-cholesterol metabolismus MeSH
- LDL-receptory metabolismus MeSH
- lidé MeSH
- lipoproteiny LDL * metabolismus MeSH
- separace krevních složek MeSH
- trombocyty * metabolismus MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
Extracorporal elimination is used for selective removal of LDL-cholesterol in severe hypercholesterolaemias. Tests are still going on to find more reliable markers which would sufficiently determine the intensity of the therapy immediately after completion of the procedure, in order to attenuate atherosclerosis activity. According to some literature data such a marker may be platelet aggregability. However, this marker carried out by standard methods has shown to be unreliable. The method was modified (by using various ADP dilutions for aggregation stimulation) and only then changes in aggregation could be observed immediately after completion of the procedure, namely, if there is a rapid drop in cholesterol concentration (of 6 mmol/l or more). Presently, this modification seems to be a suitable marker to determine the intensity of therapy.
Citace poskytuje Crossref.org
Literatura
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