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Determinants of circulating adiponectin in women with polycystic ovary syndrome
J. Vrbikova, K. Dvorakova, M. Hill, J. Vcelak, S. Stanicka, M. Vankova, D. Sramkova, K. Vondra, B. Bendlova, L. Starka
Jazyk angličtina Země Švýcarsko
Grantová podpora
NB7391
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
Karger Journals
od 1978 do 2009
ProQuest Central
od 1998-01-01 do 2015-12-31
Medline Complete (EBSCOhost)
od 2005-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1998-01-01 do 2015-12-31
PubMed
15942248
DOI
10.1159/000086273
Knihovny.cz E-zdroje
- MeSH
- adiponektin * krev MeSH
- androgeny krev MeSH
- biologické markery krev MeSH
- dospělí MeSH
- ghrelin MeSH
- globulin vázající pohlavní hormony metabolismus MeSH
- glykemický clamp MeSH
- index tělesné hmotnosti MeSH
- inzulinová rezistence MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- peptidové hormony krev MeSH
- regresní analýza MeSH
- syndrom polycystických ovarií * epidemiologie krev MeSH
- testosteron krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
BACKGROUND AND AIM: Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome. METHODS: Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression. RESULTS: The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin. CONCLUSIONS: Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further. Copyright (c) 2005 S. Karger AG, Basel.
Citace poskytuje Crossref.org
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- $a BACKGROUND AND AIM: Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome. METHODS: Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression. RESULTS: The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin. CONCLUSIONS: Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further. Copyright (c) 2005 S. Karger AG, Basel.
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