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Determinants of circulating adiponectin in women with polycystic ovary syndrome
J. Vrbikova, K. Dvorakova, M. Hill, J. Vcelak, S. Stanicka, M. Vankova, D. Sramkova, K. Vondra, B. Bendlova, L. Starka
Language English Country Switzerland
Grant support
NB7391
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
Karger Journals
from 1978 to 2009
ProQuest Central
from 1998-01-01 to 2015-12-31
Medline Complete (EBSCOhost)
from 2005-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1998-01-01 to 2015-12-31
PubMed
15942248
DOI
10.1159/000086273
Knihovny.cz E-resources
- MeSH
- Adiponectin * blood MeSH
- Androgens blood MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Ghrelin MeSH
- Sex Hormone-Binding Globulin metabolism MeSH
- Glucose Clamp Technique MeSH
- Body Mass Index MeSH
- Insulin Resistance MeSH
- Leptin blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Peptide Hormones blood MeSH
- Regression Analysis MeSH
- Polycystic Ovary Syndrome * epidemiology blood MeSH
- Testosterone blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
BACKGROUND AND AIM: Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome. METHODS: Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression. RESULTS: The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin. CONCLUSIONS: Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further. Copyright (c) 2005 S. Karger AG, Basel.
References provided by Crossref.org
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- $a BACKGROUND AND AIM: Adiponectin is regarded as a possible link between adiposity and insulin resistance. Ghrelin and leptin are considered as signals of energy status. We evaluated the relationships between these peptides, androgens and insulin sensitivity in women affected by polycystic ovary syndrome. METHODS: Thirty-six women with PCOS were examined with euglycemic hyperinsulinemic clamp (to determine M/I, index of insulin sensitivity). Leptin, ghrelin, adiponectin, androgens, and SHBG were determined. Statistics was done using correlation analysis and backward stepwise multiple regression. RESULTS: The positive correlation of adiponectin with testosterone remains significant even after adjustment for BMI (p = 0.01), M/I (p = 0.009) and for both M/I and BMI (p = 0.02). In multiple regression with testosterone, M/I, leptin and ghrelin as independent variables, the model including testosterone (p = 0.03) and ghrelin (p = 0.002) explained 49% of the variability (p < 0.0012) of adiponectin. CONCLUSIONS: Both adiponectin and ghrelin can be involved in the pathophysiology of PCOS but their relation must be delineated further. Copyright (c) 2005 S. Karger AG, Basel.
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