-
Je něco špatně v tomto záznamu ?
Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia
J. Litzman, J. Nechvatalova, J. Xu, O. Ticha, M. Vlkova, Z. Hel
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
NS10398
MZ0
CEP - Centrální evidence projektů
NT11414
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
Zdroj
Zdroj
NLK
Free Medical Journals
od 1966 do Před 1 rokem
PubMed Central
od 1966 do Před 1 rokem
Medline Complete (EBSCOhost)
od 1966-01-01 do Před 1 rokem
Wiley Online Library (archiv)
od 1990-01-01 do 2012-12-31
- MeSH
- aktivace lymfocytů MeSH
- antigeny CD14 krev imunologie MeSH
- B-lymfocyty imunologie MeSH
- běžná variabilní imunodeficience krev imunologie MeSH
- bronchiektazie krev MeSH
- C-reaktivní protein imunologie metabolismus MeSH
- deficience IgA krev imunologie MeSH
- dospělí MeSH
- endotoxemie krev imunologie MeSH
- granulom krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipopolysacharidy krev imunologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nemoci jater krev MeSH
- receptor interleukinu-2 - alfa-podjednotka krev imunologie MeSH
- senioři MeSH
- splenomegalie krev MeSH
- T-lymfocyty imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4(+) T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc13012372
- 003
- CZ-PrNML
- 005
- 20170406110343.0
- 007
- ta
- 008
- 130404s2012 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/j.1365-2249.2012.04655.x $2 doi
- 035 __
- $a (PubMed)23121673
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Litzman, J. $u Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University and St Anne's University Hospital, Brno, Czech Republic; CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic
- 245 10
- $a Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia / $c J. Litzman, J. Nechvatalova, J. Xu, O. Ticha, M. Vlkova, Z. Hel
- 520 9_
- $a Common variable immunodeficiency (CVID), the most frequent symptomatic immunoglobulin primary immunodeficiency, is associated with chronic T cell activation and reduced frequency of CD4(+) T cells. The underlying cause of immune activation in CVID is unknown. Microbial translocation indicated by elevated serum levels of lipopolysaccharide and soluble CD14 (sCD14) has been linked previously to systemic immune activation in human immunodeficiency virus/acquired immune deficiency syndrome (HIV-1/AIDS), alcoholic cirrhosis and other conditions. To address the mechanisms of chronic immune activation in CVID, we performed a detailed analysis of immune cell populations and serum levels of sCD14, soluble CD25 (sCD25), lipopolysaccharide and markers of liver function in 35 patients with CVID, 53 patients with selective immunoglobulin (Ig)A deficiency (IgAD) and 63 control healthy subjects. In CVID subjects, the concentration of serum sCD14 was increased significantly and correlated with the level of sCD25, C-reactive protein and the extent of T cell activation. Importantly, no increase in serum lipopolysaccharide concentration was observed in patients with CVID or IgAD. Collectively, the data presented suggest that chronic T cell activation in CVID is associated with elevated levels of sCD14 and sCD25, but not with systemic endotoxaemia, and suggest involvement of lipopolysaccharide-independent mechanisms of induction of sCD14 production.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a antigeny CD14 $x krev $x imunologie $7 D018950
- 650 _2
- $a B-lymfocyty $x imunologie $7 D001402
- 650 _2
- $a bronchiektazie $x krev $7 D001987
- 650 _2
- $a C-reaktivní protein $x imunologie $x metabolismus $7 D002097
- 650 _2
- $a běžná variabilní imunodeficience $x krev $x imunologie $7 D017074
- 650 _2
- $a endotoxemie $x krev $x imunologie $7 D019446
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a granulom $x krev $7 D006099
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a deficience IgA $x krev $x imunologie $7 D017098
- 650 _2
- $a receptor interleukinu-2 - alfa-podjednotka $x krev $x imunologie $7 D053645
- 650 _2
- $a lipopolysacharidy $x krev $x imunologie $7 D008070
- 650 _2
- $a nemoci jater $x krev $7 D008107
- 650 _2
- $a aktivace lymfocytů $7 D008213
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a splenomegalie $x krev $7 D013163
- 650 _2
- $a T-lymfocyty $x imunologie $7 D013601
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Nechvátalová, Jana $u Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University and St Anne's University Hospital $7 xx0210356
- 700 1_
- $a Xu, J. $u Department of Pathology and Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
- 700 1_
- $a Ticha, O. $u Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University and St Anne's University Hospital
- 700 1_
- $a Vlkova, M. $u Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University and St Anne's University Hospital
- 700 1_
- $a Hel, Z. $u Department of Pathology and Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
- 773 0_
- $w MED00009471 $t Clinical and experimental immunology $x 1365-2249 $g Roč. 170, č. 3 (2012), s. 321-332
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/23121673 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20130404 $b ABA008
- 991 __
- $a 20170406110635 $b ABA008
- 999 __
- $a ok $b bmc $g 975570 $s 810653
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2012 $b 170 $c 3 $d 321-332 $i 1365-2249 $m Clinical and experimental immunology $n Clin Exp Immunol $x MED00009471
- GRA __
- $a NS10398 $p MZ0
- GRA __
- $a NT11414 $p MZ0
- LZP __
- $a Pubmed-20130404